492905 | Nucleozin - Calbiochem

492905
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₁H₁₉ClN₄O₄

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      492905-25MG
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          Glass bottle 25 mg
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          Description
          OverviewA cell-permeable isoxazolylpiperazine compound that is shown to inhibit influenza A H1N1 (A/WSN/33 strain), H3N2 (clinical isolate), and H5N1 (A/Vietnam/1194/04) replication in MDCK cells in vitro (EC50 = 69, 160, and 330 nM, respectively) and significantly reduce fatality after A/Vietnam/1194/04 infection in mice in vivo (50% survial rate on day 21 with 14 b.i.d. i.p. doses of 230 µg/mouse in the first 7 days after infection) by preventing nucleoprotein (NP) nuclear accumulation via NP aggregation induction during early stages of viral infection. Virus strains with N309K or Y289H NP mutation, such as swine-origin influenza A (S-OIV) H1N1, are found to be resistant to Nucleozin, consistent with the N309-mediated hydrogen bonding and Y289-mediated hydrophobic interaction with Nucleozin as predicted by computer-aided docking studies.
          Catalogue Number492905
          Brand Family Calbiochem®
          References
          ReferencesKao, R.Y., et al. 2010. Nat. Biotechnol. 28, 600.
          Product Information
          FormYellow powder
          Hill FormulaC₂₁H₁₉ClN₄O₄
          Chemical formulaC₂₁H₁₉ClN₄O₄
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          492905

          References

          Reference overview
          Kao, R.Y., et al. 2010. Nat. Biotechnol. 28, 600.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-October-2011 RFH
          DescriptionA cell-permeable isoxazolylpiperazine compound that is shown to inhibit influenza A H1N1 (A/WSN/33 strain), H3N2 (clinical isolate), and H5N1 (A/Vietnam/1194/04) replication in MDCK cells in vitro (EC50 = 69, 160, and 330 nM, respectively) and significantly reduce fatality after A/Vietnam/1194/04 infection in mice in vivo (50% survial rate on day 21 with 14 b.i.d. i.p. doses of 230 µg/mouse in the first 7 days after infection) by preventing nucleoprotein (NP) nuclear accumulation via NP aggregation induction during early stages of viral infection. Virus strains with N309K or Y289H NP mutation, such as swine-origin influenza A (S-OIV) H1N1, are found to be resistant to Nucleozin, consistent with the N309-mediated hydrogen bonding and Y289-mediated hydrophobic interaction with Nucleozin as predicted by computer-aided docking studies.
          FormYellow powder
          Chemical formulaC₂₁H₁₉ClN₄O₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (20 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
          Toxicity Standard Handling
          ReferencesKao, R.Y., et al. 2010. Nat. Biotechnol. 28, 600.