487928 Nocodazole - CAS 31430-18-9 - Calbiochem

487928
  
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₁₁N₃O₃S 31430-18-9
      Description
      OverviewInhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also available as a 50 mM solution in DMSO (Cat. No. 487929).
      Catalogue Number487928
      Brand Family Calbiochem®
      SynonymsR17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate
      References
      ReferencesPark, H., et al. 2011. Chem. Med. Chem. in press.
      Bunz, F., et al. 1998. Science 282, 1497.
      Fleischman, L.F., et al. 1993. Oncogene 8, 771.
      Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429.
      Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
      Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.
      Product Information
      CAS number31430-18-9
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₁₄H₁₁N₃O₃S
      Chemical formulaC₁₄H₁₁N₃O₃S
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      ApplicationNocodazole, CAS 31430-18-9, is a highly specific anti-microtubular agent that promotes tubulin depolymerization and inhibits mitosis.
      Biological Information
      Primary TargetPromotes tubulin depolymerization
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSDD6521000
      Safety Information
      R PhraseR: 40-63

      Limited evidence of a carcinogenic effect.
      Possible risk of harm to the unborn child.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Nocodazole - CAS 31430-18-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Nocodazole - CAS 31430-18-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      487928

      References

      Reference overview
      Park, H., et al. 2011. Chem. Med. Chem. in press.
      Bunz, F., et al. 1998. Science 282, 1497.
      Fleischman, L.F., et al. 1993. Oncogene 8, 771.
      Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429.
      Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
      Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.

      Brochure

      Title
      Antibiotics Profiler

      Citations

      Title
    • Meng Qiao, et al. (2006) Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. Journal of Biological Chemistry 281, 7118-7128.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-June-2012 JSW
      SynonymsR17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate
      DescriptionInhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also acts as a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK (Kd < 2 µM).
      FormPale yellow solid
      CAS number31430-18-9
      RTECSDD6521000
      Chemical formulaC₁₄H₁₁N₃O₃S
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesPark, H., et al. 2011. Chem. Med. Chem. in press.
      Bunz, F., et al. 1998. Science 282, 1497.
      Fleischman, L.F., et al. 1993. Oncogene 8, 771.
      Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429.
      Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
      Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.
      Citation
    • Meng Qiao, et al. (2006) Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. Journal of Biological Chemistry 281, 7118-7128.