487960 | Nociceptin - CAS 170713-75-4 - Calbiochem

487960
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₇₉H₁₂₉N₂₇O₂₂ 170713-75-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      487960-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewEndogenous ligand for the opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1). Has no significant activity on the µ, δ, or κ opioid receptors; however, nanomolar concentrations of nociceptin inhibit forskolin-stimulated adenylyl cyclase activity in cells transfected with the G-protein coupled receptor LC132, which is similar in sequence to the opioid receptor. Also reported to cause hypertension and bradycardia in mice.
          Catalogue Number487960
          Brand Family Calbiochem®
          SynonymsOrphanin FQ, OFQ, NC, FGGFTGARKSARKLANQ
          References
          ReferencesMadeddu, P., et al. 1999. Hypertension 33, 914.
          Sandin, J., et al. 1999. NeuroReport 10, 71.
          Meunier, J., et al. 1995. Nature 377, 532.
          Reinscheid, R.K., et al. 1995. Science 270, 792.
          Product Information
          CAS number170713-75-4
          ATP CompetitiveN
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₇₉H₁₂₉N₂₇O₂₂
          Chemical formulaC₇₉H₁₂₉N₂₇O₂₂
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetOpioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1)
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          487960

          References

          Reference overview
          Madeddu, P., et al. 1999. Hypertension 33, 914.
          Sandin, J., et al. 1999. NeuroReport 10, 71.
          Meunier, J., et al. 1995. Nature 377, 532.
          Reinscheid, R.K., et al. 1995. Science 270, 792.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-August-2008 RFH
          SynonymsOrphanin FQ, OFQ, NC, FGGFTGARKSARKLANQ
          DescriptionEndogenous ligand for the opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1). Has no significant activity at the µ, δ, or κ opioid receptors; however, nanomolar concentrations of Nociceptin inhibit, forskolin-stimulated adenylyl cyclase activity in cells transfected with the G-protein coupled receptor LC132, which is similar in sequence to the opioid receptor. Also reported to cause hypertension and bradycardia in mice.
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          CAS number170713-75-4
          Chemical formulaC₇₉H₁₂₉N₂₇O₂₂
          Peptide SequenceH-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH
          Purity≥98% by HPLC
          SolubilityH₂O (10 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
          Toxicity Standard Handling
          ReferencesMadeddu, P., et al. 1999. Hypertension 33, 914.
          Sandin, J., et al. 1999. NeuroReport 10, 71.
          Meunier, J., et al. 1995. Nature 377, 532.
          Reinscheid, R.K., et al. 1995. Science 270, 792.