538773 Nitric Oxide Production Inhibitor, 8-Gly Carb - Calbiochem

538773
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₃H₁₁ClN₄O.CF₃CH₂O

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.38773.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable carboline derived compound that acts as an inhibitor of both the constitutive (IC50 = 7 µM) and the inducible (IC50 = 7 µM and 20 µM for TNFalpha and LPS-induced) production of nitric oxide (·NO) in rat peritoneal macrophages in a manner independent of NF-κB activation. Only at higher concentrations (~ 100 µM), it inhibits NF-κB-mediated gene expression in differentiated THP1-XBlue cells. Shown to be about 40-fold more effective than NG-nitro-L-arginine in inhibiting ·NO production and 15-fold more effective in blocking LPS-induced ·NO production. Does not affect LPS- or TNFalpha-mediated cytokine production in THP1-XBlue cells and has no effect on ERK1/2 and p38 phosphorylation in TNFalpha stimulated THP1-XBlue cells.
          Catalogue Number538773
          Brand Family Calbiochem®
          Synonyms2-Amino-N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)acetamide Trifluoroacetate, NO Inhibitor, 8-Gly Carb
          References
          ReferencesGrodzki, A.C., et al. 2015. J. Pharm. Exp. Ther. 352, 438.
          Product Information
          FormBeige solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₁₃H₁₁ClN₄O.CF₃CH₂O
          Chemical formulaC₁₃H₁₁ClN₄O.CF₃CH₂O
          Hygroscopic Hygroscopic
          ReversibleY
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Nitric Oxide Production Inhibitor, 8-Gly Carb - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Grodzki, A.C., et al. 2015. J. Pharm. Exp. Ther. 352, 438.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-July-2017 JSW
          Synonyms2-Amino-N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)acetamide Trifluoroacetate, NO Inhibitor, 8-Gly Carb
          DescriptionA cell-permeable carboline derived compound that acts as an inhibitor of both the constitutive (IC50 = 7 µM) and the inducible (IC50 = 7 µM and 20 µM for TNFalpha and LPS-induced) production of nitric oxide (·NO) in rat peritoneal macrophages in a manner independent of NF-κB activation. Only at higher concentrations (~ 100 µM), it inhibits NF-κB-mediated gene expression in differentiated THP1-XBlue cells. Shown to be about 40-fold more effective than NG-nitro-L-arginine in inhibiting ·NO production and 15-fold more effective in blocking LPS-induced ·NO production. Does not affect LPS- or TNFalpha-mediated cytokine production in THP1-XBlue cells and has no effect on ERK1/2 and p38 phosphorylation in TNFalpha stimulated THP1-XBlue cells.
          FormBeige solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₃H₁₁ClN₄O.CF₃CH₂O
          Purity≥98% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesGrodzki, A.C., et al. 2015. J. Pharm. Exp. Ther. 352, 438.