482200 | Nimodipine - CAS 66085-59-4 - Calbiochem

482200
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₂₆N₂O₇ 66085-59-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      482200-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewAn L-type Ca2+ channel blocker. Enhances memory in old or brain-damaged animals. Ameliorates experimental diabetic neuropathy in streptozotocin-induced diabetic rats. Also reported to block TNF-α and LPS-induced iNOS activity (IC50 = 36 pM) in mouse astroglial cells.
          Catalogue Number482200
          Brand Family Calbiochem®
          Synonyms1,4-Dihydro-2,6-dimethyl-4-(3ʹ-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl-1-methylethyl Ester
          References
          ReferencesZhu, D., et al. 1999. Life. Sci. 65, PL 221.
          Marchetti, C. and Usai, C. 1996. Neurosci. Lett. 207, 77.
          Kappelle, A.C., et al. 1994. Br. J. Pharmacol. 111, 887.
          Weiss, J.H., et al. 1994. J. Neurochem. 62, 372.
          Kappelle, A.C., et al. 1993. Br. J. Pharmacol. 108, 780.
          Product Information
          CAS number66085-59-4
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₂₁H₂₆N₂O₇
          Chemical formulaC₂₁H₂₆N₂O₇
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetL-type Ca2+ channel blocker
          Primary Target IC<sub>50</sub>36 pM blocking TNF-α and LPS-induced iNOS activity in mouse astroglial cells
          Purity>98% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSUS7975500
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          482200

          References

          Reference overview
          Zhu, D., et al. 1999. Life. Sci. 65, PL 221.
          Marchetti, C. and Usai, C. 1996. Neurosci. Lett. 207, 77.
          Kappelle, A.C., et al. 1994. Br. J. Pharmacol. 111, 887.
          Weiss, J.H., et al. 1994. J. Neurochem. 62, 372.
          Kappelle, A.C., et al. 1993. Br. J. Pharmacol. 108, 780.

          Brochure

          Title
          Calcium Metabolism and Related Products Brochure
          Channel Blockers Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-October-2010 JSW
          Synonyms1,4-Dihydro-2,6-dimethyl-4-(3ʹ-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl-1-methylethyl Ester
          DescriptionAn L-type Ca2+ channel blocker. Enhances memory in old or brain-damaged animals. Ameliorates experimental diabetic neuropathy in streptozotocin-induced diabetic rats.
          FormYellow solid
          CAS number66085-59-4
          RTECSUS7975500
          Chemical formulaC₂₁H₂₆N₂O₇
          Structure formulaStructure formula
          Purity>98% by TLC
          SolubilityDMSO (25 mg/ml) or methanol
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          Merck USA index14, 6551
          ReferencesZhu, D., et al. 1999. Life. Sci. 65, PL 221.
          Marchetti, C. and Usai, C. 1996. Neurosci. Lett. 207, 77.
          Kappelle, A.C., et al. 1994. Br. J. Pharmacol. 111, 887.
          Weiss, J.H., et al. 1994. J. Neurochem. 62, 372.
          Kappelle, A.C., et al. 1993. Br. J. Pharmacol. 108, 780.