508148 Nefazodone Hydrochloride - CAS 82752-99-6 - Calbiochem

508148
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₅H₃₂ClN₅O2·HCl 82752-99-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.08148.0001
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          Glass bottle 10 mg
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          Description
          OverviewA potent 5-HT2A receptor antagonist (Kd = 26 nM), with moderate affinity for the alpha1-adrenergic receptor (Kd = 48 nM) and 5-HT1A receptor (Kd = 80 nM). Originally developed as a clinical antidepressant but discontinued in 2004, nefazodone (Serzone) still remains a specific inhibitor of certain serotonergic pathways. Nefazodone also has been reported to induce mitochondrial dysfuntion.
          Catalogue Number508148
          Brand Family Calbiochem®
          Synonyms5-HT2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone
          References
          ReferencesKim, J.-A. et al. 2012. Toxicol. Lett. 214, 175.
          Cusack, B. et al. 1994. Psychopharmacol. 114, 559.
          Product Information
          CAS number82752-99-6
          FormWhite solid
          Hill FormulaC₂₅H₃₂ClN₅O2·HCl
          Chemical formulaC₂₅H₃₂ClN₅O2·HCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target5-HT2A
          Primary Target K<sub>i</sub>26nM
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Kim, J.-A. et al. 2012. Toxicol. Lett. 214, 175.
          Cusack, B. et al. 1994. Psychopharmacol. 114, 559.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-October-2013 JSW
          Synonyms5-HT2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone
          DescriptionA potent 5-HT2A receptor antagonist (Kd = 26 nM), with moderate affinity for the alpha1-adrenergic receptor (Kd = 48 nM) and 5-HT1A receptor (Kd = 80 nM). Originally developed as a clinical antidepressant but discontinued in 2004, nefazodone (Serzone) still remains a specific inhibitor of certain serotonergic pathways. Nefazodone also has been reported to induce mitochondrial dysfuntion.
          FormWhite solid
          CAS number82752-99-6
          Chemical formulaC₂₅H₃₂ClN₅O2·HCl
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (25 mM) or Ethanol (10 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKim, J.-A. et al. 2012. Toxicol. Lett. 214, 175.
          Cusack, B. et al. 1994. Psychopharmacol. 114, 559.