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480066 | Necrostatin-1, Inactive Control - CAS 64419-92-7 - Calbiochem

480066
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₂H₁₁N₃OS 64419-92-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      480066-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable N-demethylated thiohydantoin analog of Nec-1 (Cat. No. 480065) that is devoid of anti-necroptotic properties and serves as a suitable inactive control.

          Note: This inactive inhibitor of necrosis should not be used in high concentration.
          Catalogue Number480066
          Brand Family Calbiochem®
          Synonyms5-(Indol-3-ylmethyl)-2-thiohydantoin, Nec-1i
          References
          ReferencesTakahashi et al. 2012. Cell Death and Disease 3, e437.
          Degterev, A., et al. 2005. Nat. Chem. Biol. 1, 112.
          Product Information
          CAS number64419-92-7
          ATP CompetitiveN
          FormLight yellow crystalline solid
          Hill FormulaC₁₂H₁₁N₃OS
          Chemical formulaC₁₂H₁₁N₃OS
          ReversibleN
          Structure formula Image
          Applications
          ApplicationNecrostatin-1, Inactive Control, CAS 64419-92-7, is a cell-permeable N-demethylated thiohydantoin analog of Nec-1 (Cat. No. 480065) without anti-necroptotic properties.
          Biological Information
          Primary TargetInactive control for Nec-1 (Cat. No. 480065)
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          480066

          References

          Reference overview
          Takahashi et al. 2012. Cell Death and Disease 3, e437.
          Degterev, A., et al. 2005. Nat. Chem. Biol. 1, 112.

          Brochure

          Title
          Calbiochem Biologics 32.1
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-January-2015 JSW
          Synonyms5-(Indol-3-ylmethyl)-2-thiohydantoin, Nec-1i
          DescriptionA cell-permeable N-demethylated thiohydantoin analog of Nec-1 (Cat. No. 480065) that is devoid of anti-necroptotic properties and serves as a suitable inactive control.

          Note: This inactive inhibitor of necrosis should not be used in high concentration.
          FormLight yellow crystalline solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number64419-92-7
          Chemical formulaC₁₂H₁₁N₃OS
          Structure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) or Methanol (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesTakahashi et al. 2012. Cell Death and Disease 3, e437.
          Degterev, A., et al. 2005. Nat. Chem. Biol. 1, 112.