480060 | Necrosis Inhibitor, IM-54 - CAS 861891-50-1 - Calbiochem

480060
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₂₃N₃O₂ 861891-50-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      480060-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable mono-indolylmaleimide compound that selectively blocks oxidative stress-induced necrotic cell death (~3 µM IM-54 prevented ~50% cell death in HL60 cells exposed to 100 µM H2O2). Does not offer protection against Etoposide- (Cat. No. 341205) induced apoptosis or display antioxidant properties. Does not affect the kinase activities of S6K1 and PKC isozymes even at concentrations as high as 50 µM.
          Catalogue Number480060
          Brand Family Calbiochem®
          Synonyms2-(1H-Indol-3-yl)-3-pentylamino-maleimide
          References
          ReferencesDodo, K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3114.
          Product Information
          CAS number861891-50-1
          ATP CompetitiveN
          FormYellow orange solid
          Hill FormulaC₁₉H₂₃N₃O₂
          Chemical formulaC₁₉H₂₃N₃O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetBlocks oxidative stress-induced necrotic cell death
          Primary Target IC<sub>50</sub>(~3 µM prevented ~50% cell death in HL60 cells exposed to 100 µM H₂O₂).
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          480060

          References

          Reference overview
          Dodo, K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3114.

          Brochure

          Title
          Calbiochem Biologics 32.1
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-April-2011 RFH
          Synonyms2-(1H-Indol-3-yl)-3-pentylamino-maleimide
          DescriptionA cell-permeable mono-indolylmaleimide compound that selectively blocks oxidative stress-induced necrotic cell death (~3 µM IM-54 prevented ~50% cell death in HL60 cells exposed to 100 µM H2O2). Does not offer protection against Etoposide- (Cat. No. 341205) induced apoptosis or display antioxidant properties. Does not affect the kinase activities of S6K1 and PKC isozymes even at concentrations as high as 50 µM.
          FormYellow orange solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number861891-50-1
          Chemical formulaC₁₉H₂₃N₃O₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (100 mg/ml) or Methanol (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesDodo, K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3114.