504528 | NVP-AAM077 Tetrasodium Hydrate - CAS 459836-30-7 - Calbiochem

504528
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₇BrN₃Na₄O₆P 459836-30-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04528.0001
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          Glass bottle 5 mg
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          Description
          OverviewA potent antagonist for NMDA receptors. Modestly higher selectivity for the NR2A than for the NR2B containing NMDA receptors (IC50 = 0.015 and 0.078 µM) but insufficient to discriminate between NR2A and NR2B-containing NMDA receptors. Widely used for researches in synaptic plastic, learning and memory, and epilepsy.
          Catalogue Number504528
          Brand Family Calbiochem®
          SynonymsNVP-AAM077, [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium hydrate, PEAQX tetrasodium hydrate, NMDA Antagonist VII
          References
          ReferencesFrizelle. P., et al. 2006. Mol. Pharmacol. 70, 1022.
          Milton, A., et al. 2013. J. Neurosci. 33, 1109.
          Kochlamazashvili, G., et al. 2012. J. Neurosci. 32, 2263.
          Kocsis, B., et al. 2012. Sleep. 35, 1011.
          Product Information
          CAS number459836-30-7
          FormWhite solid
          Hill FormulaC₁₇H₁₇BrN₃Na₄O₆P
          Chemical formulaC₁₇H₁₇BrN₃Na₄O₆P
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetNMDA receptors
          Primary Target IC<sub>50</sub>0.015 and 0.078 µM for NR2A and NR2B, respectively.
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Frizelle. P., et al. 2006. Mol. Pharmacol. 70, 1022.
          Milton, A., et al. 2013. J. Neurosci. 33, 1109.
          Kochlamazashvili, G., et al. 2012. J. Neurosci. 32, 2263.
          Kocsis, B., et al. 2012. Sleep. 35, 1011.

          Brochure

          Title
          Pathways and Biomarkers of Glutamatergic Synapse Flyer (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-March-2015 JSW
          SynonymsNVP-AAM077, [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium hydrate, PEAQX tetrasodium hydrate, NMDA Antagonist VII
          DescriptionA potent antagonist for NMDA receptors. Modestly higher selectivity for the NR2A than for the NR2B containing NMDA receptors (IC50 = 0.015 and 0.078 µM) but insufficient to discriminate between NR2A and NR2B-containing NMDA receptors. Widely used for researches in synaptic plastic, learning and memory, and epilepsy.
          FormWhite solid
          CAS number459836-30-7
          Chemical formulaC₁₇H₁₇BrN₃Na₄O₆P
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityH₂O (24 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesFrizelle. P., et al. 2006. Mol. Pharmacol. 70, 1022.
          Milton, A., et al. 2013. J. Neurosci. 33, 1109.
          Kochlamazashvili, G., et al. 2012. J. Neurosci. 32, 2263.
          Kocsis, B., et al. 2012. Sleep. 35, 1011.