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505983 | NS1738 - CAS 501684-93-1 - Calbiochem

505983
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₉Cl₂F₃N₂O₂ 501684-93-1

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      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.05983.0001
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          Glass bottle 10 mg
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          Description
          OverviewA biarylurea derivative that acts as a selective positive allosteric modulator selective for α7 nicotinic acetylcholine receptors (α7 nAChR) without substantial activity for α4β2, α3β3 and α1-containing receptors. Exhibits cognitive enhancing effects in vivo.
          Catalogue Number505983
          Brand Family Calbiochem®
          Synonyms1-(5-chloro-2-hydroxyphenyl)-3-(2-chloro-5-(trifluoromethyl)phenyl)urea, α7 nAChR positive allosteric modulator, NS1738, NS 1738, NS-1738
          References
          ReferencesFreitas, K., et al., 2013. J. Pharmacol. Exp. Ther. 344, 264.
          Timmermann, B., J. et al., 2007, Pharmacol. Exp. Ther. 323, 294.
          Faghih, R., 2007. Recent Pat CNS Drug Discov. 2, 99.
          Product Information
          CAS number501684-93-1
          FormBeige powder
          Hill FormulaC₁₄H₉Cl₂F₃N₂O₂
          Chemical formulaC₁₄H₉Cl₂F₃N₂O₂
          Structure formula Image
          Applications
          Biological Information
          Primary Targetα7 AChR
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          References

          Reference overview
          Freitas, K., et al., 2013. J. Pharmacol. Exp. Ther. 344, 264.
          Timmermann, B., J. et al., 2007, Pharmacol. Exp. Ther. 323, 294.
          Faghih, R., 2007. Recent Pat CNS Drug Discov. 2, 99.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-October-2013 JSW
          Synonyms1-(5-chloro-2-hydroxyphenyl)-3-(2-chloro-5-(trifluoromethyl)phenyl)urea, α7 nAChR positive allosteric modulator, NS1738, NS 1738, NS-1738
          DescriptionA biarylurea derivative that acts as a selective positive allosteric modulator selective for α7 nicotinic acetylcholine receptors (α7 nAChR) without substantial activity for α4β2, α3β3 and α1-containing receptors. Exhibits cognitive enhancing effects in vivo.
          FormBeige powder
          CAS number501684-93-1
          Chemical formulaC₁₄H₉Cl₂F₃N₂O₂
          Structure formula
          Purity≥99% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesFreitas, K., et al., 2013. J. Pharmacol. Exp. Ther. 344, 264.
          Timmermann, B., J. et al., 2007, Pharmacol. Exp. Ther. 323, 294.
          Faghih, R., 2007. Recent Pat CNS Drug Discov. 2, 99.