492030 NS 2028 - CAS 204326-43-2 - Calbiochem

Potent, specific, and irreversible inhibitor of soluble guanylyl cyclase.

NS 2028 - CAS 204326-43-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one

Primary Target: basal soluble guanylyl cyclase
492030
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₉H₅BrN₂O₃ 204326-43-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      492030-5MG
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          		 Plastic ampoule 5 mg
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          Description
          OverviewPotent, specific, and irreversible inhibitor of soluble guanylyl cyclase (IC50 = 30 nM for basal and 200 nM for NO-stimulated enzyme activity; IC50 = 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum).
          Catalogue Number492030
          Brand Family Calbiochem®
          Synonyms4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one
          References
          ReferencesFleming, I., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 1123.
          Olesen, S.P., et al. 1998. Br. J. Pharmacol. 123, 299.
          Product Information
          CAS number204326-43-2
          ATP CompetitiveN
          FormWhite to off-white solid
          Hill FormulaC₉H₅BrN₂O₃
          Chemical formulaC₉H₅BrN₂O₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetbasal soluble guanylyl cyclase
          Primary Target IC<sub>50</sub>30 nM for basal and 200 nM for NO-stimulated enzyme activity; 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum
          Purity≥98% by NMR
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage. DMSO stock solutions are stable for up to 1 month at -20°C and for ~8 h at 4°C. Avoid freeze/thaw cycles of solutions.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          492030

          References

          Reference overview
          Fleming, I., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 1123.
          Olesen, S.P., et al. 1998. Br. J. Pharmacol. 123, 299.

          Brochure

          Title
          Ionic Liquids Product Range
          Nitric Oxide and Oxidative Stress Brochure
          Pathways and Biomarkers of Oxidative Stress (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-April-2008 RFH
          Synonyms4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one
          DescriptionPotent, specific, and irreversible inhibitor of soluble guanylyl cyclase (IC50 = 30 nM for basal and 200 nM for NO-stimulated enzyme activity; IC50 = 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum).
          FormWhite to off-white solid
          CAS number204326-43-2
          Chemical formulaC₉H₅BrN₂O₃
          Structure formulaStructure formula
          Purity≥98% by NMR
          SolubilityDMSO (5 mg/ml), Ethanol (5 mg/ml), or CHCl₃ (1 mg/ml)
          Storage +2°C to +8°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage. DMSO stock solutions are stable for up to 1 month at -20°C and for ~8 h at 4°C. Avoid freeze/thaw cycles of solutions.
          Toxicity Standard Handling
          ReferencesFleming, I., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 1123.
          Olesen, S.P., et al. 1998. Br. J. Pharmacol. 123, 299.