492029 | NRG1-β1/HRG1-β1 EGF Domain, Human, Recombinant

492029
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      Overview

      Replacement Information

      Key Specifications Table

      Purity
      ≥97% by SDS-PAGE

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      492029-50UG
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      Stocked 
      Discontinued
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      Available
        Remaining : Will advise
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          Glass bottle 50 μg
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          Description
          OverviewRecombinant, human neuregulin 1-β1/heregulin 1-β1 epidermal growth factor-like domain (NRG1-β1/HRG1-β1 EGF Domain), consisting of amino acids 176-246 and expressed in E. coli. All NRG1 isoforms contain an EGF-like domain that is required for binding directly to the ErbB3 or ErbB4 receptor tyrosine kinases.
          Catalogue Number492029
          Brand Family Calbiochem®
          References
          ReferencesBuonanno, A., and Fischbach, G.D. 2001. Curr. Opin. Neurobiol. 11, 287.
          Adlkofer, K. and Lai, C. 2000. Glia 29, 104.
          Garratt, A.N. et al. 2000. BioEssays 22, 987.
          Karey, K.P., et al. 1988. Cancer Res. 48, 4083.
          Product Information
          FormLyophilized
          FormulationLyophilized from 0.2 µm filtered acetonitrile, TFA, BSA.
          Applications
          Biological Information
          Biological activityED₅₀ = 0.06-0.3 ng/ml as measured in a serum-free proliferation assay using MCF-7 human breast adenocarcinoma cells.
          Purity≥97% by SDS-PAGE
          Physicochemical Information
          ContaminantsEndotoxin: ≤1.0 EU/µg protein
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Certificates of Analysis

          TitleLot Number
          492029

          References

          Reference overview
          Buonanno, A., and Fischbach, G.D. 2001. Curr. Opin. Neurobiol. 11, 287.
          Adlkofer, K. and Lai, C. 2000. Glia 29, 104.
          Garratt, A.N. et al. 2000. BioEssays 22, 987.
          Karey, K.P., et al. 1988. Cancer Res. 48, 4083.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-June-2011 RFH
          DescriptionRecombinant, human neuregulin 1-β1/heregulin 1-β1 epidermal growth factor-like domain (NRG1-β1/HRG1-β1 EGF Domain), consisting of amino acids 176-246 and expressed in E. coli. All NRG1 isoforms contain an EGF-like domain that is required for binding directly to the ErbB3 or ErbB4 receptor tyrosine kinases.
          FormLyophilized
          FormulationLyophilized from 0.2 µm filtered acetonitrile, TFA, BSA.
          Purity≥97% by SDS-PAGE
          ContaminantsEndotoxin: ≤1.0 EU/µg protein
          Biological activityED₅₀ = 0.06-0.3 ng/ml as measured in a serum-free proliferation assay using MCF-7 human breast adenocarcinoma cells.
          SolubilityReconstitute to 100 µg/ml with sterile PBS containing ≥1% human or bovine serum albumin.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBuonanno, A., and Fischbach, G.D. 2001. Curr. Opin. Neurobiol. 11, 287.
          Adlkofer, K. and Lai, C. 2000. Glia 29, 104.
          Garratt, A.N. et al. 2000. BioEssays 22, 987.
          Karey, K.P., et al. 1988. Cancer Res. 48, 4083.