532759 NOX1 Inhibitor, NoxA1ds Set - Calbiochem

532759
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₄H₂₅F₃N₄O₂S

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.32759.0001
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          Glass bottle 1 set
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          Description
          OverviewA cell permeable peptide derived from the activation domain of NOXA1, with Y199A substitution that acts as a highly potent and isoform specific inhibitor of NADPH oxidase 1 (NOX1; IC50 = 19 nM). Acts by binding to NOX1 and disrupts its interaction with its activator subunit (NOXA1). Shown to block NOX1-derived production of superoxide ( O2.- ) in a reconstituted NOX1 cell-free system, but does not affect NOX2, NOX4, NOX5 or xanthine oxidase derived superoxide and has no scavenging effects on either superoxide or hydrogen peroxide. Also suppresses superoxide production in NOX1 expressing HT-29 colon carcinoma cells (IC50 = 100 nM) and in hypoxia-induced human pulmonary artery endothelial cells (HPAEC), but does not affect O2.- production in peritoneal macropages derived from NOX1-null mice. A scrambled peptide is also included as a negative control.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number532759
          Brand Family Calbiochem®
          SynonymsNADPH Oxidase 1 Inhibitor, NoxA1ds, NADPH-oxidase inhibitor, NoxA1ds
          References
          ReferencesRanayhossaini, D.J., et al. 2013. J. Bio. Chem. 288, 36437.
          Product Information
          FormWhite solid
          Formulation1 set contains 5 mg NOX1 Inhibitor, NoxA1ds (Cat. No. 5.32760.0001) and 5 mg NOX1 Inhibitor, NoxA1ds Negative Control (Cat. No. 5.32761.0001).
          Hill FormulaC₂₄H₂₅F₃N₄O₂S
          Chemical formulaC₂₄H₂₅F₃N₄O₂S
          Hygroscopic Hygroscopic
          ReversibleY
          Applications
          Biological Information
          Primary TargetNOX1
          Primary Target IC<sub>50</sub>19 nM
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceNOX1 Inhibitor, NoxA1ds: NH3-EPVDALGKAKV-CONH2
          NOX1 Inhibitor, NoxA1ds Negative Control: NH2-LVKGPDAEKVA-CONH2
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          References

          Reference overview
          Ranayhossaini, D.J., et al. 2013. J. Bio. Chem. 288, 36437.

          Brochure

          Title
          Neuroscience Solutions for productive research
          Pathways and Biomarkers of Oxidative Stress (EMD)

          Technical Info

          Title
          Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
          White Paper: Further considerations of antibody validation and usage. (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-March-2015 JSW
          SynonymsNADPH Oxidase 1 Inhibitor, NoxA1ds, NADPH-oxidase inhibitor, NoxA1ds
          FormWhite solid
          Formulation1 set contains 5 mg NOX1 Inhibitor, NoxA1ds (Cat. No. 5.32760.0001) and 5 mg NOX1 Inhibitor, NoxA1ds Negative Control (Cat. No. 5.32761.0001).
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₄H₂₅F₃N₄O₂S
          Peptide SequenceNOX1 Inhibitor, NoxA1ds: NH3-EPVDALGKAKV-CONH2
          NOX1 Inhibitor, NoxA1ds Negative Control: NH2-LVKGPDAEKVA-CONH2
          Purity≥98% by HPLC
          SolubilityH₂0 (50 mg/ml), DMSO (50 mg/ml), or Methanol (50 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesRanayhossaini, D.J., et al. 2013. J. Bio. Chem. 288, 36437.