487957 | NOC-18 - CAS 146724-94-9 - Calbiochem

487957
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄H₁₃N₅O₂ 146724-94-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      487957-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950), NOC-7 (Cat. No. 487952) and NOC-12 (Cat. No. 487955) but with an enhanced half-life. Useful for the controlled release of NO in solution. Induces dose-dependent apoptosis in macrophages. Inhibits lipoprotein oxidation induced by Cu2+ in vitro. Half-life (t½) in PBS, pH 7.4 is 3400 minutes at 22°C. Relatively stable in alkaline solution (pH ≥10.0).
          Catalogue Number487957
          Brand Family Calbiochem®
          SynonymsDETA/NO, 2,2ʹ-(Hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate
          References
          ReferencesSeccia, M., et al. 1996. Biochem. Biophys. Res. Commun. 220, 306.
          Shibuta, S., et al. 1995. Neurosci. Lett. 187, 103.
          Shimaoka, M., et al. 1995. Biochem. Biophys. Res. Commun. 209, 519.
          Diodati, J.G., et al. 1993. J. Cardiovasc. Pharmacol. 22, 287.
          Hrabie, J.A., et al. 1993. J. Org. Chem. 58,1472.
          Product Information
          CAS number146724-94-9
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₄H₁₃N₅O₂
          Chemical formulaC₄H₁₃N₅O₂
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetA nitric oxide (NO) donor
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in NaOH, aliquot and freeze (-20°C). Stock solutions in NaOH are stable for up to 24 h at -20°C. Stock solutions in H₂O or PBS, pH 7.4 are unstable; reconstitute just prior to use.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          487957

          References

          Reference overview
          Seccia, M., et al. 1996. Biochem. Biophys. Res. Commun. 220, 306.
          Shibuta, S., et al. 1995. Neurosci. Lett. 187, 103.
          Shimaoka, M., et al. 1995. Biochem. Biophys. Res. Commun. 209, 519.
          Diodati, J.G., et al. 1993. J. Cardiovasc. Pharmacol. 22, 287.
          Hrabie, J.A., et al. 1993. J. Org. Chem. 58,1472.

          Brochure

          Title
          Nitric Oxide Donors and Scavengers Technical Bulletin
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-August-2008 RFH
          SynonymsDETA/NO, 2,2ʹ-(Hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate
          DescriptionA nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950), NOC-7 (Cat. No. 487952), and NOC-12 (Cat. No. 487955) but with enhanced half-life for NO release (t½ = 3400 min; PBS, pH 7.4, 22°C). Useful for the controlled release of NO in solution. Induces dose-dependent apoptosis in macrophages. Inhibits lipoprotein oxidation induced by Cu2+ in vitro.
          FormWhite solid
          CAS number146724-94-9
          Chemical formulaC₄H₁₃N₅O₂
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityH₂O, 10 mM NaOH, or PBS (pH 7.4) (100 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution in NaOH, aliquot and freeze (-20°C). Stock solutions in NaOH are stable for up to 24 h at -20°C. Stock solutions in H₂O or PBS, pH 7.4 are unstable; reconstitute just prior to use.
          Toxicity Irritant
          ReferencesSeccia, M., et al. 1996. Biochem. Biophys. Res. Commun. 220, 306.
          Shibuta, S., et al. 1995. Neurosci. Lett. 187, 103.
          Shimaoka, M., et al. 1995. Biochem. Biophys. Res. Commun. 209, 519.
          Diodati, J.G., et al. 1993. J. Cardiovasc. Pharmacol. 22, 287.
          Hrabie, J.A., et al. 1993. J. Org. Chem. 58,1472.

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Biochemicals > Nucleotides, Nucleosides, Purines, Pyrimidines and Nucleic Acids > Nitric Oxide Donors/Precursors