480415 | NF023 - Calbiochem

480415
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₅H₂₀N₄O₂₁S₆ · 6Na

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      480415-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA suramin analog that acts as a selective and direct G-protein antagonist for α-subunits of the Go/Gi group (EC50 ~ 300 nM). Suppresses GTPγS binding to recombinant G-protein α-subunits. Acts by inhibiting the formation of the agonist-specific ternary complex (agonist/receptor/G-protein). NF023 does not interfere with the interaction between α-subunits and βγ-dimer but competes with the effector binding site. Also a P2X receptor antagonist (IC50 = 240 nM for P2X1; 8.5 µM for P2X3 receptor in rat muscle). Causes a concentration dependent inhibition of excitatory junction potentials (IC50 = 4.8 pM).
          Catalogue Number480415
          Brand Family Calbiochem®
          Synonyms8,8ʹ-[Carbonylbis(imino-3,1-phenylene)]bis-(1,3,5-naphthalenetrisulfonic Acid), 6Na, P2X Antagonist I, Purinergic Receptor P2X Antagonist I
          References
          ReferencesSnedden, P., et al. 2000. Br. J. Pharmacol. 129, 1089.
          Soto, F., et al. 1999. Neuropharmacology 38, 141.
          Beindle, W., et al. 1996. Mol. Pharmacol. 50, 415.
          Freissmuth, M., et al. 1996. Mol. Pharmacol. 49, 602.
          Product Information
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₃₅H₂₀N₄O₂₁S₆ · 6Na
          Chemical formulaC₃₅H₂₀N₄O₂₁S₆ · 6Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetα-subunits of the Go/Gi group of G-protein
          Primary Target IC<sub>50</sub>240 nM for P2X1; 8.5 µM for P2X3 receptor in rat muscle; 4.8 pM in the inhibition of excitatory junction potentials; EC50 ~ 300 nM as G-protein antagonist for α-subunits of the Go/Gi group
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          480415

          References

          Reference overview
          Snedden, P., et al. 2000. Br. J. Pharmacol. 129, 1089.
          Soto, F., et al. 1999. Neuropharmacology 38, 141.
          Beindle, W., et al. 1996. Mol. Pharmacol. 50, 415.
          Freissmuth, M., et al. 1996. Mol. Pharmacol. 49, 602.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-August-2008 RFH
          Synonyms8,8ʹ-[Carbonylbis(imino-3,1-phenylene)]bis-(1,3,5-naphthalenetrisulfonic Acid), 6Na, P2X Antagonist I, Purinergic Receptor P2X Antagonist I
          DescriptionA suramin analog that acts as a selective G-protein antagonist for α-subunits of the Go/Gi group (EC50 ~300 nM). Suppresses GTPγS binding to recombinant G-protein α-subunits. Acts by inhibiting the formation of the agonist-specific ternary complex (agonist/receptor/G-protein). NF023 does not interfere with the interaction between α-subunits βγ-dimer but competes with the effector binding site. Also a P2X receptor antagonist (IC50=0.24 µM for P2X1; 8.5 µM for P2X3 receptor in rat muscle).
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₃₅H₂₀N₄O₂₁S₆ · 6Na
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityH₂O
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
          Toxicity Standard Handling
          ReferencesSnedden, P., et al. 2000. Br. J. Pharmacol. 129, 1089.
          Soto, F., et al. 1999. Neuropharmacology 38, 141.
          Beindle, W., et al. 1996. Mol. Pharmacol. 50, 415.
          Freissmuth, M., et al. 1996. Mol. Pharmacol. 49, 602.