480030 NEMO-Binding Domain Binding Peptide, Cell-Permeable, Negative Control - Calbiochem

480030
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₅₄H₂₄₉N₄₇O₄₂S

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      480030-500UG
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      Stocked 
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          Plastic ampoule 500 μg
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          Description
          OverviewA cell-permeable Antennapedia-NBD mutated (Trp739 and Trp741 replaced with Ala) fusion peptide analog of NEMO-Binding Domain Binding Peptide (Cat. No. 480025) that serves as a negative control. Shown to be defective in binding to NEMO. Does not affect the TNF-α-induced phosphorylation of c-Jun and DNA binding of the transcription factor Oct-1.
          Catalogue Number480030
          Brand Family Calbiochem®
          SynonymsDRQIKIWFQNRRMKWKK-TALDASALQTE, NBD-Binding Peptide, Cell-Permeable, Negative Control
          References
          ReferencesJimi, E., et al. 2004. Nat. Med., 10, 617.
          May, M.J., et al. 2000. Science 289, 1550.
          Product Information
          ATP CompetitiveN
          FormLyophilized off-white solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₁₅₄H₂₄₉N₄₇O₄₂S
          Chemical formulaC₁₅₄H₂₄₉N₄₇O₄₂S
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetNegative control defective in binding to NEMO
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceH₂N-Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Thr-Ala-Leu-Asp-Ala-Ser-Ala-Leu-Gln-Thr-Glu-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          480030

          References

          Reference overview
          Jimi, E., et al. 2004. Nat. Med., 10, 617.
          May, M.J., et al. 2000. Science 289, 1550.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-August-2008 RFH
          SynonymsDRQIKIWFQNRRMKWKK-TALDASALQTE, NBD-Binding Peptide, Cell-Permeable, Negative Control
          DescriptionA cell-permeable, Antennapedia-NBD mutated (Trp739 → Ala and Trp741 → Ala) fusion peptide analog of NEMO-Binding Domain Binding peptide (Cat. No. 480025) that serves as a negative control. Reported to be defective in binding to NEMO. Does not affect the TNF-α-induced phosphorylation of c-Jun or DNA binding of the transcription factor Oct-1.
          FormLyophilized off-white solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₅₄H₂₄₉N₄₇O₄₂S
          Peptide SequenceH₂N-Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Thr-Ala-Leu-Asp-Ala-Ser-Ala-Leu-Gln-Thr-Glu-OH
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml). Note: This peptide will precipitate when added to tissue culture medium even at 100 µM concentrations; however, sufficient material will stay in solution to permeate cells.
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesJimi, E., et al. 2004. Nat. Med., 10, 617.
          May, M.J., et al. 2000. Science 289, 1550.