479975 | NDGA - CAS 500-38-9 - Calbiochem

479975
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₂₂O₄ 500-38-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      479975-250MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 250 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA cell-permeable antioxidant and a selective lipoxygenase (LOX) inhibitor (IC50 = 200 nM, 30 µM, and 30 µM for 5-LOX, 12-LOX, and 15-LOX, respectively) over cyclooxygenase (IC50 = 100 µM). Also shown to inhibit platelet-derived growth factor (PDGF)-stimulated DNA synthesis in Swiss/3T3 cells. A powerful hydroxy radical quencher.
          Catalogue Number479975
          Brand Family Calbiochem®
          SynonymsNordihydroguaiaretic Acid
          References
          ReferencesDomin, J., et al. 1994. J. Biol. Chem. 269, 8260.
          Goodman, Y., et al. 1994. Brain Res. 654, 171.
          Kozubik, A., et al. 1993. Exp. Hematol. 21, 138.
          Salari, H., et al. 1984. Prostagland. Leuk. Med. 13, 53.
          Hope, W.C., et al. 1983. Biochem. Pharmacol. 32, 367.
          Product Information
          CAS number500-38-9
          ATP CompetitiveN
          FormCrystalline solid
          Hill FormulaC₁₈H₂₂O₄
          Chemical formulaC₁₈H₂₂O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetLOX-5
          Primary Target IC<sub>50</sub>200 nM, 30 µM, and 30 µM for 5-LOX, 12-LOX, and 15-LOX, respectively
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSUX1750000
          Safety Information
          R PhraseR: 22-36/37/38

          Harmful if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          479975

          References

          Reference overview
          Domin, J., et al. 1994. J. Biol. Chem. 269, 8260.
          Goodman, Y., et al. 1994. Brain Res. 654, 171.
          Kozubik, A., et al. 1993. Exp. Hematol. 21, 138.
          Salari, H., et al. 1984. Prostagland. Leuk. Med. 13, 53.
          Hope, W.C., et al. 1983. Biochem. Pharmacol. 32, 367.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-September-2008 JSW
          SynonymsNordihydroguaiaretic Acid
          DescriptionA cell-permeable, antioxidant and a selective lipoxygenase (LO) inhibitor (IC50 = 200 nM, 30 µM, and 30 µM for 5-LO, 12-LO, and 15-LO, respectively) over cyclooxygenase (IC50 = 100 µM). Also shown to inhibit platelet-derived growth factor (PDGF)-stimulated DNA synthesis in Swiss 3T3 cells.
          FormCrystalline solid
          CAS number500-38-9
          RTECSUX1750000
          Chemical formulaC₁₈H₂₂O₄
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO (10 mg/ml) or Ethanol
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          Merck USA index14, 6693
          ReferencesDomin, J., et al. 1994. J. Biol. Chem. 269, 8260.
          Goodman, Y., et al. 1994. Brain Res. 654, 171.
          Kozubik, A., et al. 1993. Exp. Hematol. 21, 138.
          Salari, H., et al. 1984. Prostagland. Leuk. Med. 13, 53.
          Hope, W.C., et al. 1983. Biochem. Pharmacol. 32, 367.