475944 Myeloperoxidase Inhibitor-I - CAS 5351-17-7 - Calbiochem

475944
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₇H₉N₃O 5351-17-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      475944-1GM
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Plastic ampoule 1 gm
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA benzoic acid hydrazide analog that acts as a potent, irreversible, and specific inhibitor of the peroxidation activity of myeloperoxidase (MPO; IC50 = 300 nM). Does not inhibit catalase or glutathione peroxidase activities. Does not affect the production of superoxide by neutrophils. Shown to inhibit H2O2-induced apoptosis in HL-60, human leukemia cells.
          Catalogue Number475944
          Brand Family Calbiochem®
          References
          ReferencesEngelmann, I., et al. 2000. Redox Report 5, 207.
          Wagner, B.A., et al. 2000. J. Biol. Chem. 275, 22461.
          Burner, U., et al. 1999. J. Biol. Chem. 274, 9494.
          Kettle, A.J., et al. 1997. Biochem. J. 321, 503.
          Kettle, A.J., et al. 1995. Biochem. J. 308, 559.
          Product Information
          CAS number5351-17-7
          ATP CompetitiveN
          FormBeige solid
          Hill FormulaC₇H₉N₃O
          Chemical formulaC₇H₉N₃O
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMyeloperoxidase
          Primary Target IC<sub>50</sub>300 nM against myeloperoxidase (MPO)
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSDG2580000
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          475944

          References

          Reference overview
          Engelmann, I., et al. 2000. Redox Report 5, 207.
          Wagner, B.A., et al. 2000. J. Biol. Chem. 275, 22461.
          Burner, U., et al. 1999. J. Biol. Chem. 274, 9494.
          Kettle, A.J., et al. 1997. Biochem. J. 321, 503.
          Kettle, A.J., et al. 1995. Biochem. J. 308, 559.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-August-2008 RFH
          DescriptionA benzoic acid hydrazide analog that acts as a potent, specific, and irreversible inhibitor of myeloperoxidase. ABAH is a mechanism-based inhibitor that is oxidized to radical intermediates that, in turn, promote the irreversible inactivation of myeloperoxidase. Reported to inhibit hypochlorous acid (HOCl) production by purified myeloperoxidase (IC50 = 300 nM). Has also been shown to inhibit HOCl production up to 90% in zymosan and phorbol myristate acetate stimulated neutrophils (IC50 = 16 µM and 2.2 µM, respectively). Does not affect superoxide radical production or degranulation of neutrophils and does not inhibit catalase or glutathione peroxidase. Shown to inhibit myeloperoxidase-mediated apoptosis in >90% of ras-expressing fibroblasts and glutathione-depleted, src-transformed cells. Also shown to inhibit apoptosis in H2O2-treated HL-60 promyelocytic leukemia cells.
          FormBeige solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number5351-17-7
          RTECSDG2580000
          Chemical formulaC₇H₉N₃O
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) and dilute acids
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesEngelmann, I., et al. 2000. Redox Report 5, 207.
          Wagner, B.A., et al. 2000. J. Biol. Chem. 275, 22461.
          Burner, U., et al. 1999. J. Biol. Chem. 274, 9494.
          Kettle, A.J., et al. 1997. Biochem. J. 321, 503.
          Kettle, A.J., et al. 1995. Biochem. J. 308, 559.