475911 | Myeloperoxidase, Human Polymorphonuclear Leukocytes

475911
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      475911-100UG
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          Plastic ampoule 100 μg
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          Description
          OverviewNative, human myeloperoxidase from polymorphonuclear leukocytes. A lysosomal enzyme that catalyzes oxidations by hydrogen peroxide, including MPO-chloride-mediated killing of microbes and tumor cells, inactivation of chemotactic factors, and cross-linking of proteins. MPO catalyzes the formation of hypochlorous acid that kills bacteria either by binding the halide ion to intracellular constituents or by oxidation of bacterial lipids and proteins.
          Catalogue Number475911
          Brand Family Calbiochem®
          SynonymsMPO
          References
          ReferencesNauseef, W.M., et al. 1998. J. Leukocyte Biol. 63, 264.
          Panasenko, O.M., et al. 1994. Free Radic. Biol. Med. 16, 143.
          Mulligan, M.S., et al. 1992. Br. J. Pharmacol. 107, 1159.
          Sharonov, B.P., and Churilova, I.V. 1992. Biochem. Biophys. Res. Commun. 189, 1129.
          Product Information
          CAS number9003-99-0
          Unit of DefinitionOne unit is defined as the amount of enzyme that will reduce 1.0 µmol H₂O₂ per min at 25°C, pH 6.0.
          EC number1.11.1.7
          FormLyophilized
          FormulationLyophilized from 100-700 mM NaCl, 50 mM sodium acetate buffer, pH 6.0.
          Applications
          Biological Information
          Purity≥95% by SDS-PAGE
          SourcePrepared from blood that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Specific Activity150-200 units/mg protein
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C or -70°C). Stock solutions are stable for up to 1 year at -20°C or -70°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          475911

          References

          Reference overview
          Nauseef, W.M., et al. 1998. J. Leukocyte Biol. 63, 264.
          Panasenko, O.M., et al. 1994. Free Radic. Biol. Med. 16, 143.
          Mulligan, M.S., et al. 1992. Br. J. Pharmacol. 107, 1159.
          Sharonov, B.P., and Churilova, I.V. 1992. Biochem. Biophys. Res. Commun. 189, 1129.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure

          Citations

          Title
        • Armin Schnabel, Elena Csernok, Jorg Braun, Wolfgang Gross. (2000) Activation of Neutrophils, Eosinophils, and Lymphocytes in the Lower Respiratory Tract in Wegener's Granulomatosis. American Journal of Critical Care Medicine 161, 399-405.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-August-2008 RFH
          SynonymsMPO
          DescriptionNative, human myeloperoxidase from polymorphonuclear leukocytes. A lysosomal enzyme that catalyzes oxidations by hydrogen peroxide, including MPO-chloride-mediated killing of microbes and tumor cells, inactivation of chemotactic factors, and cross-linking of proteins. MPO catalyzes the formation of hypochlorous acid that kills bacteria either by binding the halide ion to intracellular constituents or by oxidation of bacterial lipids and proteins.
          FormLyophilized
          FormulationLyophilized from 100-700 mM NaCl, 50 mM sodium acetate buffer, pH 6.0.
          SourcePrepared from blood that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          CAS number9003-99-0
          EC number1.11.1.7
          Purity≥95% by SDS-PAGE
          Specific activity150-200 units/mg protein
          Unit definitionOne unit is defined as the amount of enzyme that will reduce 1.0 µmol H₂O₂ per min at 25°C, pH 6.0.
          SolubilityH₂O (volume is lot-specific and can be found on the product label). Further dilute in 100 mM NaCl, 50 mM sodium acetate, pH 6.0. Enzyme may precipitate out of solution in low ionic strength buffers or in distilled H₂O.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C or -70°C). Stock solutions are stable for up to 1 year at -20°C or -70°C.
          Toxicity Standard Handling
          ReferencesNauseef, W.M., et al. 1998. J. Leukocyte Biol. 63, 264.
          Panasenko, O.M., et al. 1994. Free Radic. Biol. Med. 16, 143.
          Mulligan, M.S., et al. 1992. Br. J. Pharmacol. 107, 1159.
          Sharonov, B.P., and Churilova, I.V. 1992. Biochem. Biophys. Res. Commun. 189, 1129.
          Citation
        • Armin Schnabel, Elena Csernok, Jorg Braun, Wolfgang Gross. (2000) Activation of Neutrophils, Eosinophils, and Lymphocytes in the Lower Respiratory Tract in Wegener's Granulomatosis. American Journal of Critical Care Medicine 161, 399-405.