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MAB1313 | Mouse Anti-Human IgG4 Antibody, clone HP6025, Fc

MAB1313
500 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H ELISA, RIA, WB M Purified Monoclonal Antibody
      Description
      Catalogue NumberMAB1313
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionMouse Anti-Human IgG4 Antibody, clone HP6025, Fc
      References
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin. Liquid in 0.2 M phosphate buffer, 0.25 M NaCl, pH 7.6, with 0.1% sodium azide.
      Applications
      ApplicationMouse anti-Human IgG4 Antibody, clone HP6025, Fc detects level of Human IgG4 & has been published & validated for use in ELISA, RIA & WB.
      Key Applications
      • ELISA
      • Radioimmunoassay
      • Western Blotting
      Application NotesThis antibody has been employed both as a capture antibody and as a detection antibody for human IgG subclass 4 in enzyme linked immunosorbent assays, radio-immunoassay and affinity immunoblots (Papadea et al., 1985; Hamilton, et al., 1987).
      Biological Information
      EpitopeFc fragment
      CloneHP6025
      HostMouse
      SpecificityHuman IgG subclass 4 Fc.

      ELISA Specificity:

      human IgG subclass 1 (0.48%)

      human IgG subclass 2 (0.08%)

      human IgG subclass 3 (0.18%)

      human IgG subclass 4 (100%)
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FCGR2B
      • CDw32
      • CD32B
      • IGFR2
      • CD32
      • Fc-gamma-RIIb
      • FCG2
      • FcRII-b
      • FCGR2
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P31994 # Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
      SIZE: 310 amino acids; 34044 Da
      SUBUNIT: Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Is the most broadly distributed Fc-gamma- receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.
      DOMAIN: SwissProt: P31994 Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.DISEASE:SwissProt: P31994 # A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.
      SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at +4°C. DO NOT FREEZE.
      Packaging Information
      Material Size500 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-HUMAN IgG SUBCLASS 4 Fc -2512474 2512474
      MOUSE ANTI-HUMAN IgG SUBCLASS 4 Fc -2595345 2595345
      MOUSE ANTI-HUMAN IgG SUBCLASS 4 Fc -2661528 2661528
      MOUSE ANTI-HUMAN IgG SUBCLASS 4 Fc -2697552 2697552
      MOUSE ANTI-HUMAN IgG SUBCLASS 4 Fc -2705230 2705230
      MOUSE ANTI-HUMAN IgG SUBCLASS 4 Fc -2710249 2710249
      MOUSE ANTI-HUMAN IgG SUBCLASS 4 Fc -2736470 2736470
      MOUSE ANTI-HUMAN IgG SUBCLASS 4 Fc -2760593 2760593
      MOUSE ANTI-HUMAN IgG SUBCLASS 4 Fc MONOCLONAL ANTIBODY - 1988282 1988282
      MOUSE ANTI-HUMAN IgG SUBCLASS 4 Fc MONOCLONAL ANTIBODY - 2012362 2012362
      MOUSE ANTI-HUMAN IgG SUBCLASS 4 Fc MONOCLONAL ANTIBODY - 2042782 2042782
      MOUSE ANTI-HUMAN IgG SUBCLASS 4 Fc MONOCLONAL ANTIBODY - 2266481 2266481
      MOUSE ANTI-HUMAN IgG SUBCLASS 4 Fc, MONOCLONAL ANTIBODY 2809919

      References

      Reference overviewPub Med ID
      Prospective randomized controlled study comparing cell block method and conventional smear method for pancreatic juice cytology.
      Yutaka Noda,Naotaka Fujita,Go Kobayashi,Kei Ito,Jun Horaguchi,Takashi Obana,Shinsuke Koshita,Yoshihide Kanno,Yasunobu Yamashita,Yuhei Kato,Takahisa Ogawa,Takashi Tsuchiya,Masaya Oikawa,Takashi Sawai,Hiroyuki Kanno,Akira Kurose
      Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 24 2012

      Show Abstract
      22507091 22507091
      Diagnostic efficacy of the cell block method in comparison with smear cytology of tissue samples obtained by endoscopic ultrasound-guided fine-needle aspiration.
      Yutaka Noda,Naotaka Fujita,Go Kobayashi,Kei Itoh,Jun Horaguchi,Osamu Takasawa,Takashi Obana,Shinsuke Koshita,Yoshihide Kanno,Takashi Suzuki,Dai Hirasawa,Toshiki Sugawara,Tetsuya Ohira,Yoshihiro Harada,Takashi Tsuchiya,Takashi Sawai,Miwa Uzuki,Akira Kurose
      Journal of gastroenterology 45 2010

      Show Abstract
      20177713 20177713
      Monoclonal antibody-based solid-phase immunoenzymometric assays for quantifying human immunoglobulin G and its subclasses in serum.
      Papadea, C, et al.
      Clin. Chem., 31: 1940-5 (1985) 1985

      Show Abstract
      3905065 3905065

      Data Sheet

      Title
      Anti-IgG4, Fc fragment, clone HP6025 - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies