531206 Mnk2 Inhibitor IV - Calbiochem

531206
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₇H₁₈N₄O₃S

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.31206.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell permeable phenylaminopyrimidine derived compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 2 (Mnk2, Ki = 370 nM. Displays high selectivity over CDK2 (Ki >10 µM) and CDK9 (Ki = 1.66 µM). Shown to block the phosphorylation of elF4E in and effectively inhibit the proliferation of MV4-11 cells (GI50 = 780 nM) by inducing a cell cycle arrest at G0/G1 phase. Diminishes the expression of Mcl-1 and causes PARP cleavage in A2780 ovarian cancer cells.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number531206
          Brand Family Calbiochem®
          SynonymsMitogen-activated protein kinase-interacting kinase 2
          References
          ReferencesDiab, S., et al. 2014. ChemMedChem. 9, 962.
          Product Information
          FormYellow powder
          Hill FormulaC₁₇H₁₈N₄O₃S
          Chemical formulaC₁₇H₁₈N₄O₃S
          ReversibleY
          Applications
          Biological Information
          Primary TargetMnk2
          Primary Target K<sub>i</sub>370 nM
          Purity>98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Mnk2 Inhibitor IV - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Diab, S., et al. 2014. ChemMedChem. 9, 962.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-December-2014 JSW
          SynonymsMitogen-activated protein kinase-interacting kinase 2
          DescriptionA cell permeable phenylaminopyrimidine derived compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 2 (Mnk2, Ki = 370 nM in MV4-11 cells). Displays high selectivity over CDK2 (Ki >10 µM) and CDK9 (Ki = 1.66 µM). Shown to block the phosphorylation of elF4E in and effectively inhibit the proliferation of MV4-11 cells (GI50 = 780 nM) by inducing a cell cycle arrest at G0/G1 phase. Diminishes the expression of Mcl-1 and causes PARP cleavage in A2780 ovarian cancer cells.
          FormYellow powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₇H₁₈N₄O₃S
          Purity>98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesDiab, S., et al. 2014. ChemMedChem. 9, 962.