475872 MnTMPyP - Calbiochem

475872
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₇₂H₆₅MnN₈O₁₃S₄

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      475872-25MG
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      Stocked 
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          Plastic ampoule 25 mg
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          Description
          OverviewCell-permeable superoxide dismutase (SOD) mimetic. Catalyzes the dismutation of O2– • (rate constant ~4 x 107 M-1 s-1) even in the presence of excess EDTA. Can substitute for SOD in mutants of E. coli lacking this enzyme. MnTMPyP acts in vivo as an NADPH/GSH:O2 oxidoreductase rather than as an SOD mimetic. Also an efficient peroxynitrite reductase when redox-coupled with biological antioxidants.
          Catalogue Number475872
          Brand Family Calbiochem®
          SynonymsMn(III)tetrakis(1-methyl-4-pyridyl)porphyrin, Tetratosylate, Hydroxide
          References
          ReferencesIzbicka, E., et al. 1999. Cancer Res. 59, 639.
          Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 6053.
          Gardner, P.R., et al. 1996. Arch. Biochem. Biophys. 325, 20.
          Liochev, S.I., and Fridovich, I. 1995. Arch. Biochem. Biophys. 321, 271.
          Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.
          Product Information
          ATP CompetitiveN
          FormBlack solid
          Hill FormulaC₇₂H₆₅MnN₈O₁₃S₄
          Chemical formulaC₇₂H₆₅MnN₈O₁₃S₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetSuperoxide dismutase (SOD) mimetic
          Purity≥95% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          475872

          References

          Reference overview
          Izbicka, E., et al. 1999. Cancer Res. 59, 639.
          Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 6053.
          Gardner, P.R., et al. 1996. Arch. Biochem. Biophys. 325, 20.
          Liochev, S.I., and Fridovich, I. 1995. Arch. Biochem. Biophys. 321, 271.
          Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Pathways and Biomarkers of Oxidative Stress (EMD)

          Citations

          Title
        • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-August-2008 JSW
          SynonymsMn(III)tetrakis(1-methyl-4-pyridyl)porphyrin, Tetratosylate, Hydroxide
          DescriptionCell-permeable superoxide dismutase (SOD) mimetic. Catalyzes the dismutation of O2– • (rate constant ~4 x 107 M-1 s-1) even in the presence of excess EDTA. Can substitute for SOD in mutants of E. coli lacking this enzyme. MnTMPyP acts in vivo as an NADPH/GSH:O2 oxidoreductase rather than as an SOD mimetic. Also an efficient peroxynitrite reductase when redox-coupled with biological antioxidants.
          FormBlack solid
          Chemical formulaC₇₂H₆₅MnN₈O₁₃S₄
          Structure formulaStructure formula
          Purity≥95% by TLC
          SolubilityH₂O (1 mg/ml)
          Storage -20°C
          Protect from moisture
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesIzbicka, E., et al. 1999. Cancer Res. 59, 639.
          Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 6053.
          Gardner, P.R., et al. 1996. Arch. Biochem. Biophys. 325, 20.
          Liochev, S.I., and Fridovich, I. 1995. Arch. Biochem. Biophys. 321, 271.
          Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.
          Citation
        • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.