530542 Mitosis Inhibitor II, Dosabulin Enantiomers Set - Calbiochem

530542
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₄H₂₂O₂S

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.30542.0001
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          Glass bottle 1 set
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          Description
          OverviewA cell-permeable bridged bicycle heptene derived compound that can arrest mitosis (EC50 = 1.23 µM) by inducing tubulin depolymerization. Inhibits the growth of U2OS osteosarcoma cells (IC50 = 810 nM) and cause apoptotic cell death. Does neither affect the binding of vinblastine to tubulin nor does it displace colchicine, but is suggested to bind to a site that is vicinal or allosteric to it, which results in a reduced binding affinity for tubulin. The R-enantiomer of this compound lacks the ability to depolymemrize tubulin (>10 µM) and is included as a negative control.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number530542
          Brand Family Calbiochem®
          SynonymsMitosis Inhibitor II, (S)-Dosabulin and Negative Control Set, (1R,4S,5S)-methyl 4-(2-(benzo[b]thiophen-2-yl)phenyl)bicyclo[3.2.1]oct-2-ene-2-carboxylate
          References
          ReferencesIbbeson, B. M., et al. 2014. Nature Comm. 5, 3155.
          Product Information
          FormOff-white solid
          Formulation1 set contains 2 mg (S)-Dosabulin (+) (Cat. No. 5.30543.0001) and 2 mg (R)-Dosabulin Negative Control (-) (Cat. No. 5.30544.0001).
          Hill FormulaC₂₄H₂₂O₂S
          Chemical formulaC₂₄H₂₂O₂S
          ReversibleY
          Applications
          Biological Information
          Primary Targettubulin
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          References

          Reference overview
          Ibbeson, B. M., et al. 2014. Nature Comm. 5, 3155.

          Technical Info

          Title
          Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
          White Paper: Further considerations of antibody validation and usage. (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-March-2015 JSW
          SynonymsMitosis Inhibitor II, (S)-Dosabulin and Negative Control Set, (1R,4S,5S)-methyl 4-(2-(benzo[b]thiophen-2-yl)phenyl)bicyclo[3.2.1]oct-2-ene-2-carboxylate
          DescriptionA cell-permeable bridged bicycle heptene derived compound that can arrest mitosis (EC50 = 1.23 µM) by inducing tubulin depolymerization. Inhibits the growth of U2OS osteosarcoma cells (IC50 = 810 nM) and cause apoptotic cell death. Does neither affect the binding of vinblastine to tubulin nor does it displace colchicine, but is suggested to bind to a site that is vicinal or allosteric to it, which results in a reduced binding affinity for tubulin. The R-enantiomer of this compound lacks the ability to depolymemrize tubulin (>10 µM) and is included as a negative control.
          FormOff-white solid
          Formulation1 set contains 2 mg (S)-Dosabulin (+) (Cat. No. 5.30543.0001) and 2 mg (R)-Dosabulin Negative Control (-) (Cat. No. 5.30544.0001).
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₄H₂₂O₂S
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesIbbeson, B. M., et al. 2014. Nature Comm. 5, 3155.