504817 | Mitochondrial Pyruvate Carrier Inhibitor, UK5099 - CAS 56396-35-1 - Calbiochem

504817
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₂N₂O₂ 56396-35-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04817.0001
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          Glass bottle 5 mg
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          5.04817.0002
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              Glass bottle 25 mg
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              Description
              OverviewA cell-permeable α-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC50 = 50 nM in rat heart mitochondria; Ki ≤ 1 µM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2 µM in human myocytes and skeletal muscle myotubes).
              Catalogue Number504817
              Brand Family Calbiochem®
              Synonyms(E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid, (E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, MPC Inhibitor, PF-1005023
              References
              ReferencesDivakaruni, A.S., et al. 2013. Proc. Natl. acad. Sci. USA 110, 5422.
              Bricker, D.K., et al. 2012. Science 337, 96.
              Herzig, S., et al. 2012. Science 337, 93.
              Hinoi, E., et al. 2006. Mol. Pharmacol. 70, 925.
              Hildyard, J.C.W., et al. 2005. Biochim. Biophys. Acta 1707, 221.
              Halestrap, A.P. 1978. Biochem. J. 172, 377.
              Halestrap, A.P. 1975. Biochem. J. 145, 85.
              Product Information
              CAS number56396-35-1
              FormBright yellow solid
              Hill FormulaC₁₈H₁₂N₂O₂
              Chemical formulaC₁₈H₁₂N₂O₂
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary Targetmitochondria
              Purity≥99% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C or -70°C). Stock solutions are stable for up to 2 weeks at -20°C or for up to 6 weeks at -70°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              References

              Reference overview
              Divakaruni, A.S., et al. 2013. Proc. Natl. acad. Sci. USA 110, 5422.
              Bricker, D.K., et al. 2012. Science 337, 96.
              Herzig, S., et al. 2012. Science 337, 93.
              Hinoi, E., et al. 2006. Mol. Pharmacol. 70, 925.
              Hildyard, J.C.W., et al. 2005. Biochim. Biophys. Acta 1707, 221.
              Halestrap, A.P. 1978. Biochem. J. 172, 377.
              Halestrap, A.P. 1975. Biochem. J. 145, 85.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision26-July-2013 JSW
              Synonyms(E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid, (E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, MPC Inhibitor, PF-1005023
              DescriptionA cell-permeable α-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC50 = 50 nM in rat heart mitochondria; Ki ≤ 1 µM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2 µM in human myocytes and skeletal muscle myotubes).
              FormBright yellow solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number56396-35-1
              Chemical formulaC₁₈H₁₂N₂O₂
              Structure formulaStructure formula
              Purity≥99% by HPLC
              SolubilityDMSO (100 mg/ml). Use only fresh DMSO for reconstitution.
              Storage +2°C to +8°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C or -70°C). Stock solutions are stable for up to 2 weeks at -20°C or for up to 6 weeks at -70°C.
              Toxicity Standard Handling
              ReferencesDivakaruni, A.S., et al. 2013. Proc. Natl. acad. Sci. USA 110, 5422.
              Bricker, D.K., et al. 2012. Science 337, 96.
              Herzig, S., et al. 2012. Science 337, 93.
              Hinoi, E., et al. 2006. Mol. Pharmacol. 70, 925.
              Hildyard, J.C.W., et al. 2005. Biochim. Biophys. Acta 1707, 221.
              Halestrap, A.P. 1978. Biochem. J. 172, 377.
              Halestrap, A.P. 1975. Biochem. J. 145, 85.