530031 Mitochondria Targeting Cisplatin Analog, mtPt - Calbiochem

530031
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability

      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₅₈H₁₀₉N₂₂O₁₀Ptplus;

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.30031.0001
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Glass bottle 2 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA platinum-based cisplatin analogue (cis-{Pt(NH3)2}2+) conjugated to a mitochondria-penetrating peptide that localizes to mitochondria to induce mitochondrial DNA damage in ovarian cancer cells, but has minimal effect on normal cells. Shown to be effective even in cisplatin-resistant A2780CP70 cells (IC50 = 5.0 µM). Has a much lower resistance factor when compared to cisplatin (0.7 vs 8.7). Exhibits reduced toxicity compared to cisplatin. Diminishes the amplification of the mitochondrial, but not the nuclear DNA segment. Shown to cause a statistically significant reduction in the amplification of the mitochondrial but not nuclear DNA segment, and increases reactive oxygen species (ROS) product.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number530031
          Brand Family Calbiochem®
          SynonymsMitochondrial DNA Damaging Agent, mtPt
          References
          ReferencesWisnovsky, S.P., et al. 2013. Chem. Biol. 20, 1323.
          Product Information
          FormWhite powder
          Hill FormulaC₅₈H₁₀₉N₂₂O₁₀Ptplus;
          Chemical formulaC₅₈H₁₀₉N₂₂O₁₀Ptplus;
          Hygroscopic Hygroscopic
          Applications
          Biological Information
          Primary Target IC<sub>50</sub>5 µM in cisplatin-resistant A2780CP70 cells
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Mitochondria Targeting Cisplatin Analog, mtPt - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Wisnovsky, S.P., et al. 2013. Chem. Biol. 20, 1323.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-June-2014 JSW
          SynonymsMitochondrial DNA Damaging Agent, mtPt
          DescriptionA platinum-based cisplatin analogue (cis-{Pt(NH3)2}2+) conjugated to a mitochondria-penetrating peptide that localizes to mitochondria to induce mitochondrial DNA damage in ovarian cancer cells, but has minimal effect on normal cells. Shown to be effective even in cisplatin-resistant A2780CP70 cells (IC50 = 5.0 µM). Has a much lower resistance factor when compared to cisplatin (0.7 vs 8.7). Exhibits reduced toxicity compared to cisplatin. Diminishes the amplification of the mitochondrial, but not the nuclear DNA segment. Shown to cause a statistically significant reduction in the amplification of the mitochondrial but not nuclear DNA segment, and increases reactive oxygen species (ROS) product.
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₅₈H₁₀₉N₂₂O₁₀Ptplus;
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml). Use only fresh DMSO for reconstitution.
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
          Toxicity Standard Handling
          ReferencesWisnovsky, S.P., et al. 2013. Chem. Biol. 20, 1323.