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530310 | Mithramycin A - CAS 18378-89-7 - Calbiochem

530310
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₅₂H₇₆O₂₄ 18378-89-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.30310.0001
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          Glass bottle 2 mg
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          Description
          OverviewAn aureolic acid type tricyclic pentaglycoside antibiotics with anti-tumor properties. Binds to G-C rich DNA and displaces Sp1 transcription factor from its sites in the promoters of selected oncogenes, such as c-Myc and c-Src. Mithramycin A-induced inhibition of Sp1 activity has been linked to greater DNA damage and cell death in cells that are homozygous for SNP309. Specifically reduces the levels of MDM2 in human ductal breast epithelial tumor cell line, T47D (5-fold reduction at 200 nM), but does not affect cells that are wild-type for SNP309. Shown to induce myeloid differentiation of leukemic blasts that leads to reduction in the level of expression of c-Myc and c-Abl proto oncogenes that harbor G-C rich promoters. Inhibits Mcl-1 activity and mTOR phosphorylation (Ser2448) in prostate cancer cells without affecting normal human prostate epithelial cells. Shown to reduce expression of endogenous transient receptor potential vanilpod receptor (TRPV1)-like protein in dorsal root ganglionic neurons.
          Catalogue Number530310
          Brand Family Calbiochem®
          SynonymsPlicamycin, Mithramycin
          References
          ReferencesZavala, K., et al. 2014. Neurosci Lett. 562,in press.
          Choi, E. S., et al. 2013. J. Clin. Biochem. Nutr. 53, 89.
          Sleiman S. F., et al. 2011. J. Neurosci. 31, 6858.
          Bond, G, et al. 2004. Cell. 119, 591.
          Blume, S, et al. 1991. J. Clin. Invest. 88, 1613.
          Product Information
          CAS number18378-89-7
          FormYellow powder
          Hill FormulaC₅₂H₇₆O₂₄
          Chemical formulaC₅₂H₇₆O₂₄
          ReversibleY
          Applications
          Biological Information
          Primary TargetSp1 transcription factor
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 62-63

          Possible risk of impaired fertility.
          Possible risk of harm to the unborn child.
          S PhraseS: 36/37/39-45

          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          References

          Reference overview
          Zavala, K., et al. 2014. Neurosci Lett. 562,in press.
          Choi, E. S., et al. 2013. J. Clin. Biochem. Nutr. 53, 89.
          Sleiman S. F., et al. 2011. J. Neurosci. 31, 6858.
          Bond, G, et al. 2004. Cell. 119, 591.
          Blume, S, et al. 1991. J. Clin. Invest. 88, 1613.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-May-2014 JSW
          SynonymsPlicamycin, Mithramycin
          DescriptionAn aureolic acid type tricyclic pentaglycoside antibiotics with anti-tumor properties. Binds to G-C rich DNA and displaces Sp1 transcription factor from its sites in the promoters of selected oncogenes, such as c-Myc and c-Src. Mithramycin A-induced inhibition of Sp1 activity has been linked to greater DNA damage and cell death in cells that are homozygous for SNP309. Specifically reduces the levels of MDM2 in human ductal breast epithelial tumor cell line, T47D (5-fold reduction at 200 nM), but does not affect cells that are wild-type for SNP309. Shown to induce myeloid differentiation of leukemic blasts that leads to reduction in the level of expression of c-Myc and c-Abl proto oncogenes that harbor G-C rich promoters. Inhibits Mcl-1 activity and mTOR phosphorylation (Ser2448) in prostate cancer cells without affecting normal human prostate epithelial cells. Shown to reduce expression of endogenous transient receptor potential vanilpod receptor (TRPV1)-like protein in dorsal root ganglionic neurons.
          FormYellow powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number18378-89-7
          Chemical formulaC₅₂H₇₆O₂₄
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          ReferencesZavala, K., et al. 2014. Neurosci Lett. 562,in press.
          Choi, E. S., et al. 2013. J. Clin. Biochem. Nutr. 53, 89.
          Sleiman S. F., et al. 2011. J. Neurosci. 31, 6858.
          Bond, G, et al. 2004. Cell. 119, 591.
          Blume, S, et al. 1991. J. Clin. Invest. 88, 1613.