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475851 | Mitaplatin - Calbiochem

475851
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₀H₂₂Cl₆N₄O₆Pt

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      475851-25MG
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      Stocked 
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      Available
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          Glass bottle 25 mg
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          Description
          OverviewA cell-permeable Pt(IV) compound that, upon reduction inside cells, yields two molecules of the PDK (pyruvate dehydrogenase kinase) inhibitor DCA/dichloroacetate and one molecule of the apoptosis inducer Cisplatin (Cat. No. 232120). While the dual prodrug nature of Mitaplatin is shown to result in increased cell killing than Cisplatin in the human ovarian carcinoma A2780/CP70 cultures (IC50 = 3.34 and 6.0, respectively), the anticancer potency of Mitaplatin is often weaker than Cisplatin in other cancer cells tested, presumably due to insufficient prodrug reduction in these cells.

          Note: Carboplatin, Cisplatin, and other platinum drugs are reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Solubilization with DMSO prior to culture treatment is not recommended.
          Catalogue Number475851
          Brand Family Calbiochem®
          Synonymsc,c,t-[Pt(NH₃)₂Cl₂(O₂CCHCl₂)₂]
          References
          ReferencesHall, M.D., et al. 2014. Cancer Res. In press.
          Dhar, S., and Lippard, S.J., 2009. Proc. Natl. Acad. Sci. USA 106, 22199.
          Product Information
          FormOff-white to cream solid
          Hill FormulaC₁₀H₂₂Cl₆N₄O₆Pt
          Chemical formulaC₁₀H₂₂Cl₆N₄O₆Pt
          Structure formula Image
          Applications
          Biological Information
          Purity≥95% by NMR
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 22-36-45

          Do not breathe dust.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C. Use only fresh DMSO for reconstitution.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          475851

          References

          Reference overview
          Hall, M.D., et al. 2014. Cancer Res. In press.
          Dhar, S., and Lippard, S.J., 2009. Proc. Natl. Acad. Sci. USA 106, 22199.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-July-2014 JSW
          Synonymsc,c,t-[Pt(NH₃)₂Cl₂(O₂CCHCl₂)₂]
          DescriptionA cell-permeable Pt(IV) compound that, upon reduction inside cells, yields two molecules of the PDK (pyruvate dehydrogenase kinase) inhibitor DCA/dichloroacetate and one molecule of the apoptosis inducer Cisplatin (Cat. No. 232120). While the dual prodrug nature of Mitaplatin is shown to result in increased cell killing than Cisplatin in the human ovarian carcinoma A2780/CP70 cultures (IC50 = 3.34 and 6.0, respectively), the anticancer potency of Mitaplatin is often weaker than Cisplatin in other cancer cells tested, presumably due to insufficient prodrug reduction in these cells.

          Note: Carboplatin, Cisplatin, and other platinum drugs are reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Solubilization with DMSO prior to culture treatment is not recommended.
          FormOff-white to cream solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₀H₂₂Cl₆N₄O₆Pt
          Structure formula
          Purity≥95% by NMR
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C. Use only fresh DMSO for reconstitution.
          Toxicity Harmful
          ReferencesHall, M.D., et al. 2014. Cancer Res. In press.
          Dhar, S., and Lippard, S.J., 2009. Proc. Natl. Acad. Sci. USA 106, 22199.