475840 | Milrinone - CAS 78415-72-2 - Calbiochem

475840
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₂H₉N₃O 78415-72-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      475840-10MG
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          Alu drum 10 mg
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          Description
          OverviewA cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 300 nM). Has positive chronotropic, inotropic, and vasodilatory effects on the heart.
          Catalogue Number475840
          Brand Family Calbiochem®
          Synonyms1,6-Dihydro-2-methyl-6-oxo-(3,4ʹ-bipyridine)-5-carbonitrile
          References
          ReferencesBailey, J.M., et al. 1994. Anesthesiology 81, 616.
          Wilhelm, D., et al. 1992. J. Cardiovasc. Pharmacol. 20, 705.
          Lindgren, S.H., et al. 1990. Acta. Phys. Scand. 140, 209.
          Harrison, S.A., et al. 1986. Mol. Pharmacol. 29, 506.
          Product Information
          CAS number78415-72-2
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₂H₉N₃O
          Chemical formulaC₁₂H₉N₃O
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPDE 3
          Primary Target IC<sub>50</sub>300 nM against PDE III
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSDW1762000
          Safety Information
          R PhraseR: 23/24/25

          Toxic by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36/37/39-45

          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          475840

          References

          Reference overview
          Bailey, J.M., et al. 1994. Anesthesiology 81, 616.
          Wilhelm, D., et al. 1992. J. Cardiovasc. Pharmacol. 20, 705.
          Lindgren, S.H., et al. 1990. Acta. Phys. Scand. 140, 209.
          Harrison, S.A., et al. 1986. Mol. Pharmacol. 29, 506.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-July-2014 JSW
          Synonyms1,6-Dihydro-2-methyl-6-oxo-(3,4ʹ-bipyridine)-5-carbonitrile
          DescriptionA cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III, IC50 = 300 nM). Has positive chronotropic, ionotropic, and vasodilatory effects on the heart.
          FormWhite solid
          CAS number78415-72-2
          RTECSDW1762000
          Chemical formulaC₁₂H₉N₃O
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (20 mg/ml) or Ethanol (3 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Toxic
          Merck USA index14, 6197
          ReferencesBailey, J.M., et al. 1994. Anesthesiology 81, 616.
          Wilhelm, D., et al. 1992. J. Cardiovasc. Pharmacol. 20, 705.
          Lindgren, S.H., et al. 1990. Acta. Phys. Scand. 140, 209.
          Harrison, S.A., et al. 1986. Mol. Pharmacol. 29, 506.