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FCABS131F | Milli-Mark Anti-TBX21/T-Bet-FITC Antibody

100 tests  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H FC Rb FITC Polyclonal Antibody
      Catalogue NumberFCABS131F
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark Anti-TBX21/T-Bet-FITC Antibody
      Alternate Names
      • TBX21
        T-box transcription factor
        T-box 21
      Background InformationTBX21 (T-box transcription factor, also known as T-Bet) is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Studies in mouse show that TBX21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma. Expression of the human ortholog also correlates with IFN-G expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. TBX21 initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs. Genetic variations in TBX21 are associated with susceptibility to asthma and nasal polyps
      Product Information
      • Jurkat cells
      Presentation Purified rabbit polyclonal conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      ApplicationThis Milli-Mark Anti-TBX21/T-Bet-FITC Antibody is validated for use in FC for the detection of TBX21/T-Bet.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenKLH conjugated synthetic peptide corresponding to a.a. 34-49 of human T-Bet.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityAntibody recognizes TBX21/T-Bet.
      Species Reactivity
      • Human
      Species Reactivity NoteTested and passed on Human. Unconjugated part number 09-717 is known to work with Mouse and Rat.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight58 kDa Observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using Jurkat cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information

      Related Products & Applications

      Related Products

      Catalog Number Description  
      09-717 Anti-TBX21/T-Bet Antibody Show Pricing & Availability
      MABF80 Anti-T-bet (TBX21) Antibody, clone 12E4.1 Show Pricing & Availability

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      Life Science Research > Antibodies and Assays > Primary Antibodies