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FCMAB410PE | Milli-Mark® Anti-BACE Antibody, CT-PE, clone 61-3E7

100 tests  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H FC M Phycoerythrin Monoclonal Antibody
      Catalogue NumberFCMAB410PE
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark® Anti-BACE Antibody, CT-PE, clone 61-3E7
      Alternate Names
      • Aspartyl protease 2
      • ASP2
      • Asp 2
      • Beta-site amyloid precursor protein cleaving enzyme 1
      • Beta-site APP cleaving enzyme 1
      • Memapsin-2
      • Membrane-associated aspartic protease 2
      Background InformationAlzheimer's disease (AD) is characterized by the progressive formation in the brain of insoluble amyloid plaques and vascular deposits consisting of the 4-kD amyloid b-peptide (Ab). Ab generation is initiated by proteolytic cleavage of the amyloid precursor protein (APP) at the N-terminal of Ab by b-secretase. The Ab peptide is then released by proteolytic cleavage at its C-terminus by g-secretase. Because both these proteases are prime candidates for therapeutic intervention, an intense search has been underway to identify these two enzymes. A human transmembrane aspartic-protease (Asp2), referred to as BACE, has been characterized and shown to have all the properties of b-secretase. Four groups in all have now confirmed that BACE (or Asp2) is a convincing candidate for b-secretase.

      BACE is an N-glycosylated integral membrane aspartyl protease with Mr=70 kDa. Mature BACE is produced from the immature form through a series of post-translational proteolytic cleavages and glycosylation. Sequence analysis has revealed that the immature form of BACE contains an N-terminal signal sequence (residues 1-21) followed by a large catalytic domain, a single transmembrane domain (residues 461-477), and a short cytoplasmic domain (residues 478-501). The signal sequence (1-21) is cleaved from the immature form by a signal peptidase located in the endoplasmic reticulum (ER), yielding the proBACE protein (Mr=75 kDa) which starts at residue 22. The proBACE protein is modified by cleavage of 24 N-terminal residues (aa 22-45), producing the mature BACE protein.
      Product Information
      • U251 cells
      PresentationPurified mouse monoclonal IgG1 conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      ApplicationThis Milli-Mark BACE antibody is validated for use in Flow for the detection of the Milli-Mark BACE protein.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenSynthetic peptide corresponding to C-terminus of Human BACE.
      SpecificityAntibody recognizes human BACE (beta-site APP cleaving enzyme).
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene.
      Gene Symbol
      • BACE1
      • KIAA1149
      • BACE
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P56817 # Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

      SIZE: 501 amino acids; 55764 Da

      SUBUNIT: Monomer. Interacts with GGA1, GGA2 and GGA3. Interacts with RTN3 and RTN4.

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.


      SIMILARITY: SwissProt: P56817 ## Belongs to the peptidase A1 family.
      Molecular WeightAntibody recognizes multiple isoforms for BACE, calculated molecular weights ranging from 48 to 55 kDa.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using U251 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies