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FCMAB224F | Milli-Mark™ Anti-Sca-1-FITC Antibody, clone E13 161-7

100 tests  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M FC R FITC Monoclonal Antibody
      Catalogue NumberFCMAB224F
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark™ Anti-Sca-1-FITC Antibody, clone E13 161-7
      Alternate Names
      • Lymphocyte antigen 6A-2/6E-1
      • Ly-6A.2/Ly-6E.1
      • Stem cell antigen 1
      • T-cell-activating protein
      • TAP
      Background InformationStem cell antigen-1, or Sca-1, is a murine cell surface antigen which is also called Ly6A/E or Ly6D. Sca-1 is essential for HSC differentiation. Once initial differentiation occurs, Sca-1 presence on the cell surface will continue to further influence differentiation; as is seen in skeletal muscle cells that have formed from HSC and which further differentiate into neural and endothelial cells. As such, the identification and characterization of these differentiation cascades might enhance clinical disease therapy by enhancing understanding of the way that Sca-1 is involved in HSC homing and migration. There is evidence to suggest that bone marrow stem cells are signaled by the injured tissue for release into the circulation where they differentiate and proceed to the problem area. Additionally, evidence suggests that aggressive breast cancer tumors express higher levels of Sca-1; that expression of this stem cell marker is up-regulated in cancer. A problem with the migration mechanisms influenced by Sca-1 might result in a prolonged diseased state. The gene encoding this antigen has been cloned independently as TAP (T-cell activating protein) by Reiser et al. (1988), who referred to the encoded protein as Ly6.2. The antigen is expressed on immature hematopoietic progenitor cells and, together with other markers, defines hematopoietic stem cells. Antibodies directed against Sca-1 are used to fractionate early hematopoietic progenitor cells that have the ability to repopulate bone marrow in vivo and are thus considered to represent very early forms of murine hematopoietic stem cells.
      Product Information
      • mouse bone marrow
      PresentationPurified rat monoclonal IgG2a conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      ApplicationMilli-Mark Anti-Sca-1-FITC Antibody, clone E13 161-7 is an antibody against Sca-1 for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenMouse Pre-T cell hybridoma
      CloneE13 161-7
      SpecificityAntibody recognizes stem cell antigen-1 (Sca-1).
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Ly6a
      • Ly6
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight14 kDa Calculated
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using mouse bone marrow
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies