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FCMAB198F | Milli-Mark™ Anti-CD54-FITC Antibody, clone 6.5B5

100 tests  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H FC M FITC Monoclonal Antibody
      Catalogue NumberFCMAB198F
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark™ Anti-CD54-FITC Antibody, clone 6.5B5
      Alternate Names
      • Intercellular adhesion molecule 1
      • ICAM-1
      • Major group rhinovirus receptor
      Background InformationThe CD54 antigen is a single chain glycoprotein with a molecular mass of 90 kDa (Springer, 1990). It is the human intercellular adhesion molecule-1 (ICAM-1) belonging to the immunoglobulin supergene family. The ligand for ICAM-1 is LFA-1 (leucocyte function associated-1 protein) (Berendt, 1992). ICAM-1 is widely expressed on many cell types, although the degree of expression by unstimulated resting cells varies. As a cellular activation antigen the expression of ICAM-1 is up-regulated upon cell activation, being induced particularly in response to cytokines such as interleukin-1, tumor necrosis factor, and interferon- (Berendt, 1992; Wellicome, 1990; Thornhill, 1990). ICAM-1 might be a receptor for rhinovirus (Staunton, 1989). In rejecting kidneys the antibody stains all infiltrating cells strongly as well as glomerulus epithelium, endothelium on capillaries, large vessels, and mesangium (Waugh, 1989).
      Product Information
      • Human Lymphocytes
      PresentationPurified Mouse monoclonal IgG1 conjugated to FITC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.
      ApplicationMilli-Mark Anti-CD54-FITC Antibody, clone 6.5B5 is an antibody against CD54 for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenTNF-activated human umbilical vein endothelial cells
      SpecificityAntibody recognizes Human CD54 antigen.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor.
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
      Molecular Weight 90 kDa (Springer, 1990)
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using human lymphocytes
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Milli-Mark Anti-CD54-FITC, clone 6.5B5 - 2159674 2159674
      Milli-Mark Anti-CD54-FITC, clone 6.5B5 - 1970349 1970349
      Milli-Mark Anti-CD54-FITC, clone 6.5B5 - 2063189 2063189
      Milli-Mark Anti-CD54-FITC, clone 6.5B5 - 2188556 2188556
      Milli-Mark Anti-CD54-FITC, clone 6.5B5 - NRG1774110 NRG1774110
      Milli-Mark™ Anti-CD54-FITC, -2591918 2591918
      Milli-Mark™ Anti-CD54-FITC, -2635716 2635716
      Milli-Mark™ Anti-CD54-FITC, -2638035 2638035
      Milli-Mark™ Anti-CD54-FITC, -2719872 2719872
      Milli-Mark™ Anti-CD54-FITC, -2724314 2724314
      Milli-Mark™ Anti-CD54-FITC, -2769081 2769081
      Milli-Mark™ Anti-CD54-FITC, -2820746 2820746
      Milli-Mark™ Anti-CD54-FITC, clone 6.5B5 - 2429689 2429689

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      Life Science Research > Antibodies and Assays > Primary Antibodies