474700 | Mevastatin - CAS 73573-88-3 - Calbiochem

474700
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₃H₃₄O₅ 73573-88-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      474700-50MG
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          Plastic ampoule 50 mg
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          Description
          OverviewAn antibiotic that acts as a potent inhibitor of HMG-CoA reductase, thus suppressing Ras farnesylation. Inhibitor of myoblast fusion. Also may induce bone morphogenic protein-2 (BMP-2). Causes cell cycle arrest in late G1 phase.
          This is an inactive form which may require activation for use with isolated cells depending upon the application. To activate, treat with NaOH in ethanol and then neutralize to pH 7.2.
          Catalogue Number474700
          Brand Family Calbiochem®
          SynonymsCompactin
          References
          ReferencesSugiyama, M., et al. 2000. Biochem. Biophys. Res. Commun. 271, 688.
          Hug, T., et al. 1995. Pflugers Archiv. Eur. J. Physiol. 429, 682.
          Belo, R.S., et al. 1993. Mol. Cell. Biochem. 126, 159.
          McLeish, K.R., et al. 1993. Biochem. Biophys. Res. Commun. 197, 763.
          Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
          Jackson, J.H., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 3042.
          Kita, T., et al. 1980. J. Clin. Invest. 66, 1094.
          Product Information
          CAS number73573-88-3
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₃H₃₄O₅
          Chemical formulaC₂₃H₃₄O₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetHMG-CoA reductase
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSEK7907100
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          474700

          References

          Reference overview
          Sugiyama, M., et al. 2000. Biochem. Biophys. Res. Commun. 271, 688.
          Hug, T., et al. 1995. Pflugers Archiv. Eur. J. Physiol. 429, 682.
          Belo, R.S., et al. 1993. Mol. Cell. Biochem. 126, 159.
          McLeish, K.R., et al. 1993. Biochem. Biophys. Res. Commun. 197, 763.
          Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
          Jackson, J.H., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 3042.
          Kita, T., et al. 1980. J. Clin. Invest. 66, 1094.

          Brochure

          Title
          Biologics 32.4 ( 1.19 MB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-August-2008 RFH
          SynonymsCompactin
          DescriptionAn antibiotic that acts as a potent inhibitor of HMG-CoA reductase, thus suppresses Ras farnesylation. Inhibitor of myoblast fusion. Causes cell cycle arrest in late G1 phase. May induce bone morphogenic protein-2 (BMP-2). This product requires activation for use in cell culture and cell-free assay systems. To activate, treat with ethanol solution with 1 N NaOH and then neutralize with 1 N HCl to pH 7.2 (see Keyomarsi, K . et al. 1991).
          FormWhite solid
          CAS number73573-88-3
          RTECSEK7907100
          Chemical formulaC₂₃H₃₄O₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityEthanol
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          Merck USA index14, 6164
          ReferencesSugiyama, M., et al. 2000. Biochem. Biophys. Res. Commun. 271, 688.
          Hug, T., et al. 1995. Pflugers Archiv. Eur. J. Physiol. 429, 682.
          Belo, R.S., et al. 1993. Mol. Cell. Biochem. 126, 159.
          McLeish, K.R., et al. 1993. Biochem. Biophys. Res. Commun. 197, 763.
          Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
          Jackson, J.H., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 3042.
          Kita, T., et al. 1980. J. Clin. Invest. 66, 1094.