506419 | Methysergide Maleate - CAS 129-49-7 - Calbiochem

506419
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₂₇N₃O₂·C₄H₄O₄ 129-49-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.06419.0001
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          Glass bottle 10 mg
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          Description
          OverviewAn antagonist of the 5-HT2B (pki = 8.0-9.4) and 5-HT2C (pki = 8.6-9.1) receptor. At the 5-HT1A and some other 5-HT receptors it serves as a partial agonist. It is known to have partial agonist effects on other 5-HT receptors as well. In neuronal and platelet culture, Methysergide blocks serotonin action with an IC50 = 18 µM. Originally developed in the 1960′s as a migraine/cluster headache treatment, but discontinued due to significant physiological and pyschotropic side effects. Methysergide is still actively used in research as a 5-HT2 receptor antagonist in both in vivo and in vitro experiments.
          Catalogue Number506419
          Brand Family Calbiochem®
          Synonyms5-HT Serotonin Receptor Antagonsit, Methysergide Maleate, UML-491
          References
          ReferencesMatsuta, Y. et al. 2013. Exp. Neurol. 247, 250.
          IUHPAR Database 2013.
          Shad, K.F., Saeed, S.A. 2007. Exp. Brain Res. 183, 411.
          Knight, A.R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
          Saxena, P.R and Lawang, A. 1985. Arch. Int. Pharmacodyn. Ther. 277, 235.
          Colpaert, F. C. et al. 1979. Eur. J. Pharmacol. 58, 505.
          Product Information
          CAS number129-49-7
          FormOff-white solid
          Hill FormulaC₂₁H₂₇N₃O₂·C₄H₄O₄
          Chemical formulaC₂₁H₂₇N₃O₂·C₄H₄O₄
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target5-HT
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 25

          Toxic if swallowed.
          S PhraseS: 36/37/39-46

          Wear suitable protective clothing, gloves and eye/face protection.
          If swallowed, seek medical advice immediately and show this container or label.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Matsuta, Y. et al. 2013. Exp. Neurol. 247, 250.
          IUHPAR Database 2013.
          Shad, K.F., Saeed, S.A. 2007. Exp. Brain Res. 183, 411.
          Knight, A.R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
          Saxena, P.R and Lawang, A. 1985. Arch. Int. Pharmacodyn. Ther. 277, 235.
          Colpaert, F. C. et al. 1979. Eur. J. Pharmacol. 58, 505.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-October-2013 JSW
          Synonyms5-HT Serotonin Receptor Antagonsit, Methysergide Maleate, UML-491
          DescriptionAn antagonist of the 5-HT2B (pki = 8.0-9.4) and 5-HT2C (pki = 8.6-9.1) receptor. At the 5-HT1A and some other 5-HT receptors it serves as a partial agonist. It is known to have partial agonist effects on other 5-HT receptors as well. In neuronal and platelet culture, Methysergide blocks serotonin action with an IC50 = 18 µM. Originally developed in the 1960′s as a migraine/cluster headache treatment, but discontinued due to significant physiological and pyschotropic side effects. Methysergide is still actively used in research as a 5-HT2 receptor antagonist in both in vivo and in vitro experiments.
          FormOff-white solid
          CAS number129-49-7
          Chemical formulaC₂₁H₂₇N₃O₂·C₄H₄O₄
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityH₂O (10 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic
          ReferencesMatsuta, Y. et al. 2013. Exp. Neurol. 247, 250.
          IUHPAR Database 2013.
          Shad, K.F., Saeed, S.A. 2007. Exp. Brain Res. 183, 411.
          Knight, A.R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
          Saxena, P.R and Lawang, A. 1985. Arch. Int. Pharmacodyn. Ther. 277, 235.
          Colpaert, F. C. et al. 1979. Eur. J. Pharmacol. 58, 505.