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504905 | Memantine Hydrochloride - CAS 41100-52-1 - Calbiochem

504905
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₂H₂₁N•HCl 41100-52-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04905.0001
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          Glass bottle 50 mg
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          Description
          OverviewA very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors (IC50 = 0.8, 0.57, 0.52, and 0.54 µM for GluN2A, B, C, and D, respectively). A popular medicine for treating moderate-to-severe Alzheimer′s disease. Frequently used in studying brain functions and disorders involving neurotransmission mediated by NMDA receptors (i.e. learning and memory, cognitive functions, neuroplasticity, Alzheimer′s disease, schizophrenia, bipolar depression, obsessive-compulsive disorders, oxidative stress, and excitotoxicity).
          Catalogue Number504905
          Brand Family Calbiochem®
          Synonyms3,5-Dimethyl-1-adamantanamine hydrochloride
          References
          ReferencesLimapichat, W., et al. 2012. ACS Chem. Neurosci. 4, 255.
          Anand, A., et al. 2012. Bipolar Dis. 14, 64.
          Lopes, P., et al. 2013. Brain and Behavior. 3, 67.
          Howard, R., et al. 2012. New Eng. J. Med. 366, 893.
          Parsons, G., et al. 1999. Neuropharmacol. 38, 735.
          Lee, G., et al. 2012. Psychiatry Investig. 9, 166.
          Product Information
          CAS number41100-52-1
          FormWhite solid
          Hill FormulaC₁₂H₂₁N•HCl
          Chemical formulaC₁₂H₂₁N•HCl
          Structure formula Image
          Applications
          Biological Information
          Primary TargetNMDA receptors
          Primary Target IC<sub>50</sub>0.8, 0.57, 0.52, and 0.54 →M for GluN2A, B, C, and D, respectively.
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          References

          Reference overview
          Limapichat, W., et al. 2012. ACS Chem. Neurosci. 4, 255.
          Anand, A., et al. 2012. Bipolar Dis. 14, 64.
          Lopes, P., et al. 2013. Brain and Behavior. 3, 67.
          Howard, R., et al. 2012. New Eng. J. Med. 366, 893.
          Parsons, G., et al. 1999. Neuropharmacol. 38, 735.
          Lee, G., et al. 2012. Psychiatry Investig. 9, 166.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-July-2013 JSW
          Synonyms3,5-Dimethyl-1-adamantanamine hydrochloride
          DescriptionA very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors (IC50 = 0.8, 0.57, 0.52, and 0.54 µM for GluN2A, B, C, and D, respectively). A popular medicine for treating moderate-to-severe Alzheimer′s disease. Frequently used in studying brain functions and disorders involving neurotransmission mediated by NMDA receptors (i.e. learning and memory, cognitive functions, neuroplasticity, Alzheimer′s disease, schizophrenia, bipolar depression, obsessive-compulsive disorders, oxidative stress, and excitotoxicity).
          FormWhite solid
          CAS number41100-52-1
          Chemical formulaC₁₂H₂₁N•HCl
          Structure formula
          Purity≥98% by HPLC
          SolubilityH₂O (100 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLimapichat, W., et al. 2012. ACS Chem. Neurosci. 4, 255.
          Anand, A., et al. 2012. Bipolar Dis. 14, 64.
          Lopes, P., et al. 2013. Brain and Behavior. 3, 67.
          Howard, R., et al. 2012. New Eng. J. Med. 366, 893.
          Parsons, G., et al. 1999. Neuropharmacol. 38, 735.
          Lee, G., et al. 2012. Psychiatry Investig. 9, 166.