444605 | Melittin - CAS 37231-28-0 - Calbiochem

444605
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₃₁H₂₂₉N₃₉O₃₁ 37231-28-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      444605-250UG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 250 μg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA 26-residue polypeptide from bee venom that binds calmodulin in a Ca2+-dependent manner. A stimulator of Giα and G11α activity that is reported to inhibit adenylate cyclase activity in synaptic membranes. Activates phospholipase A2 and inhibits protein kinase C (IC50 = 5-7 µM) by binding to the catalytic domain in a Mg2+-ATP sensitive manner. Has also been used for affinity purification of several Ca2+-binding proteins.
          Catalogue Number444605
          Brand Family Calbiochem®
          References
          ReferencesFukushima, N., et al. 1998. Peptides 19, 811.
          Gravitt, K.R. 1994. Biochem. Pharmacol. 47, 425.
          Baudier, J., et al. 1987. Biochemistry 26, 2886.
          Kincaid, R.L., and Coulson, C.C. 1985. Biochem. Biophys. Res. Commun. 133, 256.
          Product Information
          CAS number37231-28-0
          ATP CompetitiveN
          FormLyophilized
          Hill FormulaC₁₃₁H₂₂₉N₃₉O₃₁
          Chemical formulaC₁₃₁H₂₂₉N₃₉O₃₁
          ReversibleN
          Sold on the basis of peptide contentY
          Applications
          Biological Information
          Primary TargetPKC
          Primary Target IC<sub>50</sub>5-7 µM 5-7 µM for activating phospholipase A2 and inhibits protein kinase C
          Purity>97% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide ContentY
          Peptide SequenceH-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSOS3960000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          444605

          References

          Reference overview
          Fukushima, N., et al. 1998. Peptides 19, 811.
          Gravitt, K.R. 1994. Biochem. Pharmacol. 47, 425.
          Baudier, J., et al. 1987. Biochemistry 26, 2886.
          Kincaid, R.L., and Coulson, C.C. 1985. Biochem. Biophys. Res. Commun. 133, 256.

          Brochure

          Title
          Calcium Metabolism and Related Products Brochure
          Calmodulin and Related Products Technical Bulletin
          PKC Pathway Poster PDF ( 676 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-May-2008 RFH
          DescriptionA 26-residue polypeptide from bee venom that binds calmodulin in a Ca2+-dependent manner, activates phospholipase A2, and inhibits protein kinase C (IC50 = 5-7 µM) by binding to the catalytic domain in a Mg2+-ATP sensitive manner. A stimulator of Giα and G11α activity that is reported to inhibit adenylate cyclase activity in synaptic membranes. Has also been used for affinity purification of several Ca2+-binding proteins. Activates Giα-1 and G11α activities and inhibits Gs activity.
          FormLyophilized
          CAS number37231-28-0
          RTECSOS3960000
          Chemical formulaC₁₃₁H₂₂₉N₃₉O₃₁
          Peptide SequenceH-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH₂
          Purity>97% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          Merck USA index14, 5824
          ReferencesFukushima, N., et al. 1998. Peptides 19, 811.
          Gravitt, K.R. 1994. Biochem. Pharmacol. 47, 425.
          Baudier, J., et al. 1987. Biochemistry 26, 2886.
          Kincaid, R.L., and Coulson, C.C. 1985. Biochem. Biophys. Res. Commun. 133, 256.