505207 | Mecamylamine Hydrochloride - CAS 826-39-1 - Calbiochem

505207
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₁H₂₁N•HCl 826-39-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.05207.0001
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 10 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA potent, nonselective, and noncompetitive antagonist of nAChRs (IC50 = 640 nM, 2.5 µM, 3.6 µM and 6.9 µM for α3β4, α4β2, α3β2 and α7 subtype nAChRs, respectively). Biologically viable admitted orally or systematically. Widely used in investigating the roles of central nAChRs in the brain functions (learning and memory, decision making, cognition) and disorders (addiction, Autisms, Tourette's syndrome, Schizophrenia and various cognitive and mood disorders).
          Catalogue Number505207
          Brand Family Calbiochem®
          SynonymsN,2,3,3-Tetramethylbicyclo[2.2.1]he­ptan-2-amine hydrochloride, TC-5214, Inversine, nAChR Antagonist, Mecamylamine hydrochloride
          References
          ReferencesHarris, C., et al. 2013. Psychopharmacol. 225, 291.
          Lima, H., et al. 2013. Learning & Memory 20, 120.
          Arnold, E., et al. 2012. J. Child Adolesc. Psychopharmacol. 22, 198.
          Bacher, I., et al. 2009. Expert Opin. Pharmacother. 10, 2709.
          Lippiello, M., et al. 2008. CNS Neurosci. Ther. 14, 266.br>J. M. Young et al. 2001. Clin. Ther. 23, 532.
          Product Information
          CAS number826-39-1
          FormOff-white solid
          Hill FormulaC₁₁H₂₁N•HCl
          Chemical formulaC₁₁H₂₁N•HCl
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetnAChR
          Primary Target IC<sub>50</sub>640 nM
          Purity≥98% by TLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 25-36/37/38

          Toxic if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 22-26-28.1-36/37/39-46-63

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          After contact with skin, wash immediately with plenty of water.
          Wear suitable protective clothing, gloves and eye/face protection.
          If swallowed, seek medical advice immediately and show this container or label.
          In case of accident by inhalation: remove casualty to fresh air and keep at rest.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          505207

          References

          Reference overview
          Harris, C., et al. 2013. Psychopharmacol. 225, 291.
          Lima, H., et al. 2013. Learning & Memory 20, 120.
          Arnold, E., et al. 2012. J. Child Adolesc. Psychopharmacol. 22, 198.
          Bacher, I., et al. 2009. Expert Opin. Pharmacother. 10, 2709.
          Lippiello, M., et al. 2008. CNS Neurosci. Ther. 14, 266.br>J. M. Young et al. 2001. Clin. Ther. 23, 532.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-July-2013 JSW
          SynonymsN,2,3,3-Tetramethylbicyclo[2.2.1]he­ptan-2-amine hydrochloride, TC-5214, Inversine, nAChR Antagonist, Mecamylamine hydrochloride
          DescriptionA potent, nonselective, and noncompetitive antagonist of nAChRs (IC50 = 640 nM, 2.5 µM, 3.6 µM and 6.9 µM for α3β4, α4β2, α3β2 and α7 subtype nAChRs, respectively). Biologically viable admitted orally or systematically. Widely used in investigating the roles of central nAChRs in the brain functions (learning and memory, decision making, cognition) and disorders (addiction, Autisms, Tourette's syndrome, Schizophrenia and various cognitive and mood disorders).
          FormOff-white solid
          CAS number826-39-1
          Chemical formulaC₁₁H₂₁N•HCl
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityH₂O (100 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic
          ReferencesHarris, C., et al. 2013. Psychopharmacol. 225, 291.
          Lima, H., et al. 2013. Learning & Memory 20, 120.
          Arnold, E., et al. 2012. J. Child Adolesc. Psychopharmacol. 22, 198.
          Bacher, I., et al. 2009. Expert Opin. Pharmacother. 10, 2709.
          Lippiello, M., et al. 2008. CNS Neurosci. Ther. 14, 266.br>J. M. Young et al. 2001. Clin. Ther. 23, 532.