444278 | MMP-9 Inhibitor I - CAS 1177749-58-4 - Calbiochem

444278
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₇H₃₃N₃O₅S 1177749-58-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      444278-500UG
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          Plastic ampoule 500 μg
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          Description
          OverviewA cell-permeable, potent, selective, and reversible MMP-9 Inhibitor (IC50 = 5 nM). Inhibits MMP-1 (IC50 = 1.05 µM) and MMP-13 (IC50 = 113 nM) only at much higher concentrations.
          Catalogue Number444278
          Brand Family Calbiochem®
          References
          ReferencesLevin, J.I., et al. 2001. Bioorg. Med. Chem. Lett. 11, 2189.
          Product Information
          CAS number1177749-58-4
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₂₇H₃₃N₃O₅S
          Chemical formulaC₂₇H₃₃N₃O₅S
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMMP-9
          Primary Target IC<sub>50</sub>5 nM
          Purity≥93% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          444278

          References

          Reference overview
          Levin, J.I., et al. 2001. Bioorg. Med. Chem. Lett. 11, 2189.

          Citations

          Title
        • White A.R, et al. 2006. journal of Biological Chemistry 281, 17670.
        • Michelle K.Y. Siu and C. Yan Cheng. 2004. Biology of Reproduction 70, 945.
        • Lubbe, WL, et al. 2006. Clin. Cancer Res. 12 1876.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-April-2011 RFH
          DescriptionA cell-permeable, potent, selective, and reversible inhibitor of MMP-9 (IC50 = 5 nM). Also inhibits MMP-1 (IC50 = 1.05 µM) and MMP-13 IC50 = 113 nM) at higher concentrations.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1177749-58-4
          Chemical formulaC₂₇H₃₃N₃O₅S
          Structure formulaStructure formula
          Purity≥93% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesLevin, J.I., et al. 2001. Bioorg. Med. Chem. Lett. 11, 2189.
          Citation
        • White A.R, et al. 2006. journal of Biological Chemistry 281, 17670.
        • Michelle K.Y. Siu and C. Yan Cheng. 2004. Biology of Reproduction 70, 945.
        • Lubbe, WL, et al. 2006. Clin. Cancer Res. 12 1876.