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CC1057 | MMP-7, human, recombinant

CC1057
10 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Key ApplicationsEntrez Gene NumberSpeciesUni Prot Number
      FUNC NM_002423.3 Human P09237
      Description
      Catalogue NumberCC1057
      ReplacesAG905
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionMMP-7, human, recombinant
      OverviewMOLECULAR WT:

      28,924 Daltons calculated from primary amino acid sequence.
      Alternate Names
      • Pro-matrilysin
      References
      Product Information
      PresentationSolution in 25 mM Tris-HCl (pH 7.5), 5 mM CaCl2, 0.15 M NaCl, 0.01% Brij35 0.02% NaN3
      Applications
      Key Applications
      • Affects Function
      Biological Information
      Concentration0.1 mg/mL
      Purity~ 70% when analyzed by SDS-PAGE followed by staining with CBB R-250.
      SourceRecombinant from E. Coli
      Specific ActivitySPECIFIC ACTIVITY: <br /><br />5453 U/mg <br /><br />One unit of enzyme activity is defined as the digestion of 1 micro g of Azocoll/min. at pH 7.5 and 37°C acetate.
      Entrez Gene Number
      Entrez Gene SummaryProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
      Gene Symbol
      • MMP7
      • MPSL1
      • matrin
      • MMP-7
      • PUMP-1
      • Matrin
      • PUMP1
      • EC 3.4.24.23
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P09237 # Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
      COFACTOR: Binds 2 calcium ions per subunit. & Binds 2 zinc ions per subunit.
      SIZE: 267 amino acids; 29677 Da
      DOMAIN: SwissProt: P09237 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
      SIMILARITY: Belongs to the peptidase M10A family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -80ºC for up to one year from date of receipt.
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Protocols

      Title
      MMP Activation Chart

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RECOMBINANT HUMAN PRO-MMP-7 PROMATRILYSIN PURIFIED PROTEIN - 2122447 2122447
      RECOMBINANT HUMAN PRO-MMP-7 PROMATRILYSIN -2585932 2585932
      RECOMBINANT HUMAN PRO-MMP-7 PROMATRILYSIN -2681168 2681168
      RECOMBINANT HUMAN PRO-MMP-7 PROMATRILYSIN -2705172 2705172
      RECOMBINANT HUMAN PRO-MMP-7 PROMATRILYSIN -2716163 2716163
      RECOMBINANT HUMAN PRO-MMP-7 PROMATRILYSIN -2820224 2820224

      References

      Reference overviewPub Med ID
      Matrilysin-dependent elastolysis by human macrophages.
      Filippov, Sergey, et al.
      J. Exp. Med., 198: 925-35 (2003) 2003

      Show Abstract
      12963695 12963695

      Data Sheet

      Title
      MMP-7, human, recombinant - Data Sheet