444285 | MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem

444285
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₇NO₅S₃ 869577-53-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      444285-500UG
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          Plastic ampoule 500 μg
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          Description
          OverviewA cell-permeable sulfonamido analog of SB-3CT (Cat. No. 444274) that displays enhanced aqueous solubility and improved selectivity (Ki = 16 nM, 180 nM, and 900 nM for MMP-2, MMP-9, and MMP-14, respectively). Inhibits MMP-3, MMP-7, and MMP-1 only at much higher concentrations (Ki = 3.6 µM, 295 µM, and > 25 µM, respectively). Binds to the enzyme active site and acts as an irreversible inhibitor. Reported to potently suppress cell migration and invasion of HT1080 cells (80% inhibition at 2 µM and > 25% inhibition at 100 nM, respectively). Unlike the general MMP inhibitor GM6001 (Cat. No. 364205), this inhibitor does not block the activation of cellular pro-MMP-2 by MT1-MMP.
          Catalogue Number444285
          Brand Family Calbiochem®
          Synonyms(4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methylthiirane, SB-3CT, pMS
          References
          ReferencesIkejiri, M., et al. 2005. J. Biol. Chem. 280, 33992.
          Product Information
          CAS number869577-53-7
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₆H₁₇NO₅S₃
          Chemical formulaC₁₆H₁₇NO₅S₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMMP-2
          Primary Target K<sub>i</sub>16 nM, 180 nM, and 900 nM for MMP-2, MMP-9, and MMP-14, respectively
          Purity≥85% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          444285

          References

          Reference overview
          Ikejiri, M., et al. 2005. J. Biol. Chem. 280, 33992.

          Brochure

          Title
          Biologics 32.3 PDF ( 927 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-April-2011 RFH
          Synonyms(4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methylthiirane, SB-3CT, pMS
          DescriptionA cell-permeable sulfonamido analog of SB-3CT (Cat. No. 444274) that displays enhanced aqueous solubility and improved selectivity (Ki = 16 nM, 180 nM, and 900 nM for MMP-2, MMP-9, and MMP-14, respectively). Inhibits MMP-3, MMP-7, and MMP-1 only at much higher concentrations (Ki = 3.6 µM, 295 µM, and >25 µM, respectively). Binds to the enzyme active site and acts as an irreversible inhibitor. Reported to potently suppress cell migration and invasion of HT1080 cells (80% inhibition at 2 µM and >25% inhibition at 100 nM, respectively). Unlike the general MMP inhibitor GM6001 (Cat. No. 364205), this inhibitor does not block the activation of cellular pro-MMP-2 by MT1-MMP.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number869577-53-7
          Chemical formulaC₁₆H₁₇NO₅S₃
          Structure formulaStructure formula
          Purity≥85% by HPLC
          SolubilityDMSO (200 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesIkejiri, M., et al. 2005. J. Biol. Chem. 280, 33992.