444258 | MMP-14 Substrate I, Fluorogenic - Calbiochem

444258
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      444258-1MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Plastic ampoule 1 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA specific fluorescence resonance energy transfer (FRET) peptide substrate for the detection of MMP activity. (kcat/Km = 7.3 x 105 M-1s-1 for MMP-14 (MT1-MMP) and 3.6 x 104 M-1s-1 for MMP-11 at 25°C, pH 7.5).
          Catalogue Number444258
          Brand Family Calbiochem®
          SynonymsMCA-PLA-C(OMeBz)-WAR(Dpa)-NH₂, MT1-MMP Substrate I, Fluorogenic
          References
          ReferencesMucha, A., et al. 1998. J. Biol. Chem. 273, 2763.
          Product Information
          ATP CompetitiveN
          FormYellow lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₆₆H₈₂N₁₆O₁₇S
          Chemical formulaC₆₆H₈₂N₁₆O₁₇S
          ReversibleN
          Applications
          Biological Information
          Primary TargetMMP-14
          Primary Target IC<sub>50</sub>kcat/Km = 7.3 x 105 M-1s-1 for MMP-14; .6 x 104 M-1s-1 for MMP-11
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Emission max.
          Excitation max.
          Peptide SequenceMCA-Pro-Leu-Ala-Cys(p-OMeBz)-Trp-Ala-Arg(Dpa)-NH₂ Dpa = N³-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl, Bz = Benzyl
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          444258

          References

          Reference overview
          Mucha, A., et al. 1998. J. Biol. Chem. 273, 2763.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-March-2009 JSW
          SynonymsMCA-PLA-C(OMeBz)-WAR(Dpa)-NH₂, MT1-MMP Substrate I, Fluorogenic
          DescriptionA fluorescence resonance energy transfer (FRET) peptide substrate for the detection of MMP activity (kcat/km = 730,000 M-1s-1 for MMP-14 (MT1-MMP) and 36,000 M-1s-1 for MMP-11 (ST3); pH = 7.5 at 25°C). Excitation max.: ~328 nm; emission max.: ~400 nm.
          FormYellow lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₆₆H₈₂N₁₆O₁₇S
          Peptide SequenceMCA-Pro-Leu-Ala-Cys(p-OMeBz)-Trp-Ala-Arg(Dpa)-NH₂ Dpa = N³-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl, Bz = Benzyl
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesMucha, A., et al. 1998. J. Biol. Chem. 273, 2763.