475880 | ML-7, Hydrochloride - CAS 110448-33-4 - Calbiochem

475880
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₇IN₂O₂S · HCl 110448-33-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      475880-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). Inhibits protein kinase A (Ki = 21 µM) and protein kinase C (Ki = 42 µM) at much higher concentrations.
          Catalogue Number475880
          Brand Family Calbiochem®
          Synonyms1-(5-Iodonaphthalene-1-sulfonyl)homopiperazine, HCl
          References
          ReferencesKrarup, T., et al. 1998. Am. J. Physiol. 275, C239.
          Saitoh, M., et al. 1987. J. Biol. Chem. 262, 7796.
          Product Information
          CAS number110448-33-4
          ATP CompetitiveY
          FormWhite solid
          Hill FormulaC₁₅H₁₇IN₂O₂S · HCl
          Chemical formulaC₁₅H₁₇IN₂O₂S · HCl
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          ApplicationML-7, Hydrochloride, CAS 110448-33-4, is a cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM).
          Biological Information
          Primary TargetMyosin light chain kinase (Mlck)
          Primary Target K<sub>i</sub>300 nM against myosin light chain kinase
          Purity>98% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          475880

          References

          Reference overview
          Krarup, T., et al. 1998. Am. J. Physiol. 275, C239.
          Saitoh, M., et al. 1987. J. Biol. Chem. 262, 7796.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-January-2010 RFH
          Synonyms1-(5-Iodonaphthalene-1-sulfonyl)homopiperazine, HCl
          DescriptionA cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). Inhibits protein kinase A (Ki = 21 µM) and protein kinase C (Ki = 42 µM) at much higher concentrations.
          FormWhite solid
          CAS number110448-33-4
          Chemical formulaC₁₅H₁₇IN₂O₂S · HCl
          Structure formulaStructure formula
          Purity>98% by TLC
          SolubilityDMSO (4.5 mg/ml) or 50% ethanol (4.5 mg/ml). Further dilute with aqueous buffer just prior to use.
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
          Toxicity Standard Handling
          ReferencesKrarup, T., et al. 1998. Am. J. Physiol. 275, C239.
          Saitoh, M., et al. 1987. J. Biol. Chem. 262, 7796.