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14-537M | MKK6/SKK3 (S599D, T603D) Protein, active, 250 µg

250 µg  Also available in 10 μg size (cat#14-537) and in bulk (cat#14-537-K).
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      Replacement Information
      Catalogue Number14-537M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionMKK6/SKK3 (S599D, T603D) Protein, active, 250 µg
      OverviewN-terminal MBP tagged, recombinant, human MKK6/SKK3 residues 4-end containing S599D and T603D mutations.
      Product Information
      ApplicationActive, N-terminal MBP tagged, recombinant, human MKK6/SKK3 residues 4-end containing S599D & T603D mutations. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceHuman MKK6/SKK3 expressed in E. coli
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
      Gene Symbol
      • MAP2K6
      • PRKMK6
      • MEK6
      • SAPKK3
      • MAPKK6
      • MKK6
      Protein TargetMKK6
      Purification MethodAmylose Agarose
      Target Sub-FamilySTE
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P52564 # Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38 exclusively.
      SIZE: 334 amino acids; 37492 Da
      SUBUNIT: Interacts with Yersinia yopJ.
      TISSUE SPECIFICITY: Isoform 2 is only expressed in skeletal muscle. Isoform 1, on the other hand, is found in skeletal muscle, heart, and in lesser extent in liver or pancreas.
      PTM: Weakly autophosphorylated. & Acetylation of Ser-207 and Thr-211 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
      SIMILARITY: SwissProt: P52564 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.
      Molecular Weight80.6kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of p38α/SAPK2a, unactive (14-252).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-537) and in bulk (cat#14-537-K).
      Transport Information
      Supplemental Information


      Related Products & Applications

      Alternative Packsize

      Catalog Number Description  
      14-537 MKK6/SKK3 (S599D, T603D) Protein, active, 10 µg Show Pricing & Availability

      Product Families


      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases
      Life Science Research > Proteins and Enzymes > Purified Kinases