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46-641MAG | MILLIPLEX MAP Phospho STAT5A/B (Tyr694/699) Magnetic Bead MAPmate - Cell Signaling Single Plex or Multiplex Assay

96-well plate  
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      Replacement Information

      Key Specifications Table

      Analytes AvailableSpecies ReactivityKey ApplicationsDetection Methods
      STAT5A/B (Tyr694/699) H, M, R Mplex Luminex xMAP
      Catalogue Number46-641MAG
      Trade Name
      DescriptionMILLIPLEX MAP Phospho STAT5A/B (Tyr694/699) Magnetic Bead MAPmate - Cell Signaling Single Plex or Multiplex Assay
      Background InformationSTAT5A/B
      • Also known as “signal transducer and activator of transcription 5,” referring to two highly related proteins, STAT5A and STAT5B
      • Plays a role in cytosolic signaling, cell growth, proliferation, differentiation, and inflammation
      • Implicated in a wide range of cancers
      Materials Required but Not Delivered• MILLIPLEX MAP Cell Signaling Buffer and Detection Kit (Catalog #48-602)
      Product Information
      Detection methodLuminex xMAP
      ConfigurationSingle Plex
      Panel TypeCell Signaling
      ApplicationMAPmate single plexes allow you to design your own cell signaling panel. The analyte available for this kit is STAT5A/B (Tyr694/699).
      Key Applications
      • Multiplexing
      Application Notes• An overnight (4°C) incubation is recommended for best results
      • This assay requires 25 µL diluted cell lysate per well
      • Please consult the buffer compatibility chart or protocol for appropriate buffer choice
      • 1 - 25 μg cell lysate/well (recommended starting concentration is 20 μg)
      Biological Information
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Analytes Available
      • STAT5A/B (Tyr694/699)
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
      Gene Symbol
      • STAT5A
      • MGF
      • STAT5
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P51692 # Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.
      SIZE: 787 amino acids; 89866 Da
      SUBUNIT: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7.
      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocated into the nucleus in response to phosphorylation (By similarity).
      PTM: Tyrosine phosphorylated (By similarity).
      DISEASE: SwissProt: P51692 # Defects in STAT5B are the cause of Laron type dwarfism II (LTD2) [MIM:245590]; also known as Laron syndrome type II or Laron syndrome due to a post-receptor defect. The phenotypic features are consistent with growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, and resistance to hexogeneous hormone therapy.
      SIMILARITY: SwissProt: P51692 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsRecommended storage for kit components is 2 - 8°C
      Packaging Information
      Material Size96-well plate
      Transport Information
      Supplemental Information



      Protocol: Phospho STAT5A/B (Tyr694/Tyr699) Magnetic Bead MAPmate™


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