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46-692MAG | MILLIPLEX MAP Phospho H2A.X (Ser139) Magnetic Bead MAPmate- Cell Signaling Single Plex

96-well plate  
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      Replacement Information

      Key Specifications Table

      Analytes AvailableSpecies ReactivityKey ApplicationsDetection Methods
      H2A.X (Ser139) H, M Mplex Luminex xMAP
      Catalogue Number46-692MAG
      Trade Name
      DescriptionMILLIPLEX MAP Phospho H2A.X (Ser139) Magnetic Bead MAPmate- Cell Signaling Single Plex
      Materials Required but Not Delivered• MILLIPLEX MAP Cell Signaling Buffer and Detection Kit (Catalog #48-602)
      Background InformationH2A.X
      • Involved in gene regulation and chromatin packaging
      • H2A is a core histone which multimerizes with other histones
      • The C-terminus of H2A.X is involved with DNA repair
      Product Information
      Detection methodLuminex xMAP
      ConfigurationSingle Plex
      Panel TypeCell Signaling
      ApplicationMAPmate single plexes allow you to design your own cell signaling panel. The analyte available for this kit is H2A.X (Ser139).
      Key Applications
      • Multiplexing
      Application Notes• An overnight (4°C) incubation is recommended for best results
      • These assays require 25 µL diluted cell lysate per well
      • Please consult the buffer compatibility chart or protocol for appropriate buffer choice
      • 1 - 25 μg cell lysate/well (recommended starting concentration is 20 μg)
      Biological Information
      Species Reactivity
      • Human
      • Mouse
      Analytes Available
      • H2A.X (Ser139)
      Entrez Gene Number
      Entrez Gene SummaryHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif
      • Phosphorylation
      UniProt Number
      UniProt Summary[FUNCTION] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsRecommended storage for kit components is 2 - 8°C
      Packaging Information
      Material Size96-well plate
      Transport Information
      Supplemental Information



      Phospho H2A.X (Ser139) Magnetic Bead MAPmate™



      Safety Data Sheet (SDS) 


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