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46-608MAG | MILLIPLEX MAP HSP27 (total) Magnetic Bead MAPmate - Cell Signaling Single Plex

96-well plate  
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      Replacement Information

      Key Specifications Table

      Analytes AvailableSpecies ReactivityKey ApplicationsDetection Methods
      HSP27 (Total) H Mplex Luminex xMAP
      Catalogue Number46-608MAG
      Trade Name
      DescriptionMILLIPLEX MAP HSP27 (total) Magnetic Bead MAPmate - Cell Signaling Single Plex
      Background InformationHSP27
      • Short for Heat shock protein 27
      • Functions as a protein chaperone, inhibiting apoptosis, cell development and differentiation
      • Phosphorylated HSP27 is present in some muscle diseases, neurodegenerative diseases and various cancers
      Materials Required but Not Delivered• MILLIPLEX MAP Cell Signaling Buffer and Detection Kit (Catalog #48-602)
      Product Information
      Detection methodLuminex xMAP
      ConfigurationSingle Plex
      Panel TypeCell Signaling
      ApplicationMAPmate single plexes allow you to design your own cell signaling panel. The analyte available in this kit is HSP27 (Total).
      Key Applications
      • Multiplexing
      Application Notes• An overnight (4°C) incubation is recommended for best results
      • These assays require 25 µL diluted cell lysate per well
      • Please consult the buffer compatibility chart or protocol for appropriate buffer choice
      • 1 - 25 μg cell lysate/well (recommended starting concentration is 20 μg)
      Biological Information
      Species Reactivity
      • Human
      Analytes Available
      • HSP27 (Total)
      Entrez Gene Number
      Gene Symbol
      • HSPB1
      • HspB1
      • HS.76067
      • HMN2B
      • Hs.76067
      • HSP27
      • Hsp25
      • HSP28
      • CMT2F
      • DKFZp586P1322
      • SRP27
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P04792 # Involved in stress resistance and actin organization.
      SIZE: 205 amino acids; 22783 Da SUBUNIT: Interacts with TGFB1I1 (By similarity). Associates with alpha- and beta-tubulin and microtubules. Interacts with HSPB8 and HSPBAP1.
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock.
      PTM: Phosphorylated in MCF-7 cells on exposure to protein kinase C activators and heat shock.
      DISEASE: SwissProt: P04792 # Defects in HSPB1 are the cause of Charcot-Marie-Tooth disease type 2F (CMT2F) [MIM:606595]. CMT2F is a form of Charcot- Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. CMT2F onset is between 15 and 25 years with muscle weakness and atrophy usually beginning in feet and legs (peroneal distribution). Upper limb involvement occurs later. CMT2F inheritance is autosomal dominant. & Defects in HSPB1 are a cause of distal hereditary motor neuropathy (dHMN) [MIM:608634]. Distal HMN is a pure motor peripheral neuropathy without sensory abnormalities.
      SIMILARITY: SwissProt: P04792 ## Belongs to the small heat shock protein (HSP20) family.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsRecommended storage for kit components is 2 - 8°C
      Packaging Information
      Material Size96-well plate
      Transport Information
      Supplemental Information



      Total HSP27 Magnetic Bead MAPmate™



      Safety Data Sheet (SDS) 


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