444145 | MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem

444145
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₂BIO₃ 562823-84-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      444145-10MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Plastic ampoule 10 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA cell-permeable boranyl-chalcone that binds strongly to MDM2 and irreversibly disrupts MDM2/p53 protein complex. Exhibits selective toxicity towards MDM2 overexpressing human breast cancer cell lines (IC50 = 10, 8.8, and 7 µM for MDA-MB-435, MDA-MB-231, and Wt-MCF7, respectively) compared to normal breast cell lines (IC50 = 75 and 63 µM for MCF-10A and MCF-12A, respectively).
          Catalogue Number444145
          Brand Family Calbiochem®
          Synonymstrans-4-Iodo, 4ʹ-boranyl-chalcone, MDM2 Antagonist IV
          References
          ReferencesKumar, S.K., et al. 2003. J. Med. Chem. 46, 2813.
          Product Information
          CAS number562823-84-1
          ATP CompetitiveN
          FormPale yellow solid
          Hill FormulaC₁₅H₁₂BIO₃
          Chemical formulaC₁₅H₁₂BIO₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMDM2
          Primary Target IC<sub>50</sub>10, 8.8, and 7 µM in selective toxicity for MDA-MB-435, MDA-MB-231, and Wt-MCF7, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          444145

          References

          Reference overview
          Kumar, S.K., et al. 2003. J. Med. Chem. 46, 2813.

          Brochure

          Title
          Interactive Pathway Calendar
          p53 Pathway Poster ( 386 KB )
          p53 Pathway Poster ( 386 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-February-2008 JSW
          Synonymstrans-4-Iodo, 4ʹ-boranyl-chalcone, MDM2 Antagonist IV
          DescriptionA cell-permeable boranyl-chalcone compound that binds strongly to MDM2 and irreversibly disrupts MDM2/p53 protein complex formation. Exhibits selective toxicity to MDM2-overexpressing human breast cancer cell lines (IC50 = 10 µM for MDA-MB-435, 8.8 µM for MDA-MB-231, and 7 µM for Wt-MCF7) compared to normal breast cell lines (IC50 = 75 µM for MCF-10A and 63 µM for MCF-12A).
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number562823-84-1
          Chemical formulaC₁₅H₁₂BIO₃
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesKumar, S.K., et al. 2003. J. Med. Chem. 46, 2813.