444144 MDM2 Antagonist II, NSC 66811 - CAS 6964-62-1 - Calbiochem

444144
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₃H₂₀N₂O 6964-62-1

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      444144-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable, non-peptidyl, quinolinol compound that binds MDM2 with high affinity (Ki = 120 nM) and disrupts MDM2-p53 interaction. Shown to dose-dependently induce cellular accumulation of p53, MDM2, and p21 in HCT-116 human colon cancer cell line with wild-type p53.
          Catalogue Number444144
          Brand Family Calbiochem®
          Synonyms7-(Anilino(phenyl)-methyl)-2-methyl-8-quinolinol, MDM2 Inhibitor II
          References
          ReferencesLu, Y., et al. 2006. J. Med. Chem. 49, 3759.
          Product Information
          CAS number6964-62-1
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₃H₂₀N₂O
          Chemical formulaC₂₃H₂₀N₂O
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMDM2
          Primary Target K<sub>i</sub>120 nM against MDM2
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MDM2 Antagonist II, NSC 66811 - CAS 6964-62-1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          MDM2 Antagonist II, NSC 66811 - CAS 6964-62-1 - Calbiochem Certificates of Analysis

          TitleLot Number
          444144

          References

          Reference overview
          Lu, Y., et al. 2006. J. Med. Chem. 49, 3759.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-April-2011 RFH
          Synonyms7-(Anilino(phenyl)-methyl)-2-methyl-8-quinolinol, MDM2 Inhibitor II
          DescriptionA cell-permeable, non-peptidyl, quinolinol compound that binds MDM2 with high affinity (Ki = 120 nM) and disrupts MDM2-p53 interaction. Shown to dose-dependently induce cellular accumulation of p53, MDM2, and p21 in HCT-116 human colon cancer cell line with wild-type p53.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number6964-62-1
          Chemical formulaC₂₃H₂₀N₂O
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesLu, Y., et al. 2006. J. Med. Chem. 49, 3759.