443300 | MCI-186 - CAS 89-25-8 - Calbiochem

443300
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₀H₁₀N₂O 89-25-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      443300-500MG
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          Plastic ampoule 500 mg
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          Description
          OverviewA free radical scavenger and antioxidant that reduces post-ischemic brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC50 = 15 µM). Inhibits mitochondrial permeability transition pore.
          Catalogue Number443300
          Brand Family Calbiochem®
          Synonyms3-Methyl-1-phenyl-2-pyrazolin-5-one, PMP, Edaravone
          References
          ReferencesKatare, R. G., et al. 2003. Am. J. Physiol. 285, H2171.
          Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281, 921.
          Yamamoto, Y., et al. 1996. Redox. Report 2, 333.
          Watanabe, T., et al. 1994. J. Pharmacol. Exp. Ther. 268, 1597.
          Nishi, H., et al. 1989. Stroke 20, 1236.
          Product Information
          CAS number89-25-8
          ATP CompetitiveN
          FormCream-colored solid
          Hill FormulaC₁₀H₁₀N₂O
          Chemical formulaC₁₀H₁₀N₂O
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetA free radical scavenger and antioxidant
          Primary Target IC<sub>50</sub>15 µM inhibiting iron-dependent peroxidation in rat brain homogenates
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSUQ9625000
          Safety Information
          R PhraseR: 22-36/37/38-43

          Harmful if swallowed.
          Irritating to eyes, respiratory system and skin.
          May cause sensitization by skin contact.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          443300

          References

          Reference overview
          Katare, R. G., et al. 2003. Am. J. Physiol. 285, H2171.
          Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281, 921.
          Yamamoto, Y., et al. 1996. Redox. Report 2, 333.
          Watanabe, T., et al. 1994. J. Pharmacol. Exp. Ther. 268, 1597.
          Nishi, H., et al. 1989. Stroke 20, 1236.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Pathways and Biomarkers of Oxidative Stress (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-August-2008 JSW
          Synonyms3-Methyl-1-phenyl-2-pyrazolin-5-one, PMP, Edaravone
          DescriptionA free radical scavenger and antioxidant that reduces post-ischemie brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC50 = 15 µM). Inhibits mitochondrial permeability transition pore.
          FormCream-colored solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number89-25-8
          RTECSUQ9625000
          Chemical formulaC₁₀H₁₀N₂O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          Merck USA index14, 6713
          ReferencesKatare, R. G., et al. 2003. Am. J. Physiol. 285, H2171.
          Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281, 921.
          Yamamoto, Y., et al. 1996. Redox. Report 2, 333.
          Watanabe, T., et al. 1994. J. Pharmacol. Exp. Ther. 268, 1597.
          Nishi, H., et al. 1989. Stroke 20, 1236.