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14-586 | MAPKAP Kinase 3 Protein, unactive, 50 µg

50 µg  
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      Replacement Information
      Catalogue Number14-586
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionMAPKAP Kinase 3 Protein, unactive, 50 µg
      OverviewN-terminal, GST-tagged, recombinant, human MAPKAP Kinase 3, amino acids 2-end
      Product Information
      ApplicationUnactive, N-terminal, GST-tagged, recombinant, human MAPKAP Kinase 3, amino acids 2-end, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Application NotesActivation Assay
      Biological Information
      Sourceexpressed in E.coli cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.
      Gene Symbol
      • MAPKAPK3
      • MAPKAP
      • MAPKAP3
      • 3PK
      • MAPKAPK-3
      • 3pK
      Protein TargetMAPKAP-K3
      Purification MethodGlutathione agarose affinity chromatography
      Target Sub-FamilyCAMK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q16644 # Modulator of polycomb-mediated repression, which can be activated either by ERK, p38 and JNK. Substrate of CSBP. In vitro, phosphorylates HSPB1, BMI1/PCGF4 and TCF3.
      SIZE: 382 amino acids; 42987 Da
      SUBUNIT: Interacts with TCF3 and with polycomb proteins, such as PCH2 and BMI1/PCGF4.
      SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly located in the nucleus, when activated it translocates to the cytoplasm.
      TISSUE SPECIFICITY: Widely expressed, with a higher expression level observed in heart and skeletal muscle. No expression in brain.
      SIMILARITY: SwissProt: Q16644 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain.
      Molecular Weight~69.8kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated to activate SAPK2a (14-587).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information

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      Product Families


      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases
      Life Science Research > Proteins and Enzymes > Purified Kinases